Evidence map›Paper›PMID 25585599›Full record

ArticleEuropean journal of clinical nutrition2015

Polyunsaturated fatty acids in relation to incident mobility disability and decline in gait speed; the Age, Gene/Environment Susceptibility-Reykjavik Study.

I Reinders, R A Murphy, X Song, M Visser, M F Cotch, T F Lang, M E Garcia, L J Launer, K Siggeirsdottir, G Eiriksdottir and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The role of omega-3 in the prevention and treatment of sarcopenia.Aging clinical and experimental research · 2019
    Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

I Reinders1] Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA [2] Department of Health Sciences and the EMGO Institute for Health and Care Research, VU UniversityAmsterdam, The Netherlands.
R A MurphyLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
X SongBiomarker Laboratory, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
M Visser1] Department of Health Sciences and the EMGO Institute for Health and Care Research, VU UniversityAmsterdam, The Netherlands [2] Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.
M F CotchDivision of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
T F LangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
M E GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
L J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
K SiggeirsdottirIcelandic Heart Association Research Institute, Kopavogur, Iceland.
G EiriksdottirIcelandic Heart Association Research Institute, Kopavogur, Iceland.
P V JonssonDepartment of Geriatrics, Landspitali National University Hospital and Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
V Gudnason1] Icelandic Heart Association Research Institute, Kopavogur, Iceland [2] Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
T B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
I A BrouwerDepartment of Health Sciences and the EMGO Institute for Health and Care Research, VU UniversityAmsterdam, The Netherlands.
National Institute on Aging · USIcelandic Heart Association · ISFred Hutch Cancer Center · USNational Eye Institute · USNational Institutes of Health · USUniversity of California, San Francisco · USUniversity of Iceland · IS

Funding

CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective studyZIAAG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2025
$6.1M
Age, Gene/environment Susceptibility Study In Iceland - Ocular ComponentZIAEY000401 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2009 to 2020
$3.3M
Gene/environment Susceptibility Iceland-Ocular ComponentZ01EY000401 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2002 to 2008
$258k
AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
–
Intramural NIH HHS Z01 EY000401Intramural NIH HHS Z99 EY999999Intramural NIH HHS ZIA EY000401NIA NIH HHS N01 AG012100NIA NIH HHS N01-AG012100
6 · The paper itself

Abstract

BACKGROUND/

objectivesLow intake of long chain polyunsaturated fatty acids (PUFAs) are associated with physical disability; however, prospective studies of circulating PUFAs are scarce. We examined associations between plasma phospholipid n-3 and n-6 PUFAs with risk of incident mobility disability and gait speed decline. SUBJECTS/

methodsData are from a subgroup of the Age, Gene/Environment Susceptibility-Reykjavik Study, a population-based study of risk factors for disease and disability in old age. In this subgroup (n = 556, mean age 75.1 ± 5.0 years, 47.5% men), plasma phospholipid PUFAs were assessed at baseline using gas chromatography. Mobility disability and usual gait speed were assessed at baseline and after 5.2 ± 0.2 years. Mobility disability was defined as the following: having much difficulty, or being unable to walk 500 m or climb up 10 steps; decline in gait speed was defined as change ⩾ 0.10 m/s. Logistic regression analyses were performed to determine associations between sex-specific s.d. increments in PUFAs with risk of incident mobility disability and gait speed decline. Odds ratios (95% confidence intervals) adjusted for demographics, follow-up time, risk factors and serum vitamin D were reported.

resultsIn women, but not men, every s.d. increment increase of total n-3 PUFAs and docosahexaenoic acid (DHA) was associated with lower mobility disability risk, odds ratio 0.48 (0.25; 0.93) and odds ratio 0.45 (0.24; 0.83), respectively. There was no association between n-6 PUFAs and the risk of incident mobility disability or gait speed decline.

conclusionsHigher concentrations of n-3 PUFAs and, particularly, DHA may protect women from impaired mobility but does not appear to have such an effect in men.

Indexed as

EnvironmentMobility LimitationAgedAged, 80 and overBody Mass IndexCross-Sectional StudiesFatty Acids, Omega-3Fatty Acids, Omega-6FemaleFollow-Up StudiesGaitHumansLogistic ModelsMaleMotor ActivityMultivariate AnalysisFatty Acids, Omega-3Fatty Acids, Omega-6

Identifiers

PMID25585599
PMCPMC4752009
OpenAlexW2094444627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.