ArticleBiomacromolecules2015
Targeted release of tobramycin from a pH-responsive grafted bilayer challenged with S. aureus.
Article in Biomacromolecules, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 74 citations in OpenAlex.
- Polydopamine-assisted smart bacteria-responsive hydrogel: Switchable antimicrobial and antifouling capabilities for accelerated wound healing.Journal of advanced research · 2025Article
- Recent Advances in Nanomedicine for Ocular Fundus Neovascularization Disease Management.Advanced healthcare materials · 2024Review
- Controlling spatial distribution of functional lipids in a supported lipid bilayer prepared from vesicles.Journal of colloid and interface science · 2024Article
- pH-Responsive Cobalt(II)-Coordinated Assembly Containing Quercetin for Antimicrobial Applications.Molecules (Basel, Switzerland) · 2023Article
- Infection-responsive long-term antibacterial bone plates for open fracture therapy.Bioactive materials · 2023Article
- Composing On-Program Triggers and On-Demand Stimuli into Biosensor Drug Carriers in Drug Delivery Systems for Programmable Arthritis Therapy.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Oxidized Chitosan-Tobramycin (OCS-TOB) Submicro-Fibers for Biomedical Applications.Pharmaceutics · 2022Article
- Stimuli-Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Research progress of stimulus-responsive antibacterial materials for bone infection.Frontiers in bioengineering and biotechnology · 2022Review
- Electrochemical immunosensor based on mussel inspired coating for simultaneous detection and elimination ofRSC advances · 2021Article
- Self-defensive antimicrobial biomaterial surfaces.Colloids and surfaces. B, Biointerfaces · 2020Article
- Responsive Assembly of Silver Nanoclusters with a Biofilm Locally Amplified Bactericidal Effect to Enhance Treatments against Multi-Drug-Resistant Bacterial Infections.ACS central science · 2019Article
- Biomaterial surfaces self-defensive against bacteria by contact transfer of antimicrobials.Biomaterials · 2019Article
- Enhanced of antibacterial activity of antibiotic-functionalized silver nanocomposites with good biocompatibility.Journal of materials science. Materials in medicine · 2019Article
- Construction of Self-defensive Antibacterial and Osteogenic AgNPs/Gentamicin Coatings with Chitosan as Nanovalves for Controlled release.Scientific reports · 2018Article
- Polyelectrolyte multilayers for bio-applications: recent advancements.IET nanobiotechnology · 2017Review
- Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles.Chemical science · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A stimuli-responsive, controlled release bilayer for the prevention of bacterial infection on biomaterials is presented. Drug release is locally controlled by the pH-responsiveness of the bilayer, comprised of an inner poly(acrylic acid) (PAA) monolayer grafted to a biomaterial and cross-linked with an outer chitosan (CH) brush. Tobramycin (TOB) is loaded in the inner PAA in part to minimize bacteria resistance. Because biofilm formation causes a decrease in local pH, TOB is released from PAA and permeates through the CH, which is in contact with the biofilm. Antibiotic capacity is controlled by the PAA thickness, which depends on PAA brush length and the extent of cross-linking between CH and PAA at the bilayer interface. This TOB-loaded, pH-responsive bilayer exhibits significantly enhanced antibacterial activity relative to controls.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.