Evidence map›Paper›PMID 25585166›Full record

ArticleTranslational psychiatry2015

Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease.

P Proitsi, M Kim, L Whiley, M Pritchard, R Leung, H Soininen, I Kloszewska, P Mecocci, M Tsolaki, B Vellas and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 4 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 7 countries.

P ProitsiInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
M KimInstitute of Pharmaceutical Science, King's College London, London, UK.
L WhileyInstitute of Pharmaceutical Science, King's College London, London, UK.
M PritchardInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
R LeungInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
H SoininenDepartment of Neurology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
I KloszewskaDepartment of Old Age Psychiatry & Psychotic Disorders, Medical University of Łódź, Łódź, Poland.
P MecocciSection of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
M TsolakiMemory and Dementia Center, 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
B VellasDepartment of Internal and Geriatrics Medicine, INSERM U 1027, Gerontopole, Hôpitaux de Toulouse, Toulouse, France.
P ShamDepartment of Psychiatry, State Key Laboratory of Brain and Cognitive Sciences, and Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
S LovestoneDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
J F PowellInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
R J B Dobson1] Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK [2] National Institute for Health Research Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK.
C Legido-QuigleyInstitute of Pharmaceutical Science, King's College London, London, UK.
King's College London · GBAristotle University of Thessaloniki · GRCentre for Mental Health · GBInserm · FRKuopio University Hospital · FIMedical University of Lodz · PLUniversity of Hong Kong · HKUniversity of Oxford · GBUniversity of Perugia · IT

Funding

Alzheimer's Society 167
6 · The paper itself

Abstract

There is an urgent need for the identification of Alzheimer's disease (AD) biomarkers. Studies have now suggested the promising use of associations with blood metabolites as functional intermediate phenotypes in biomedical and pharmaceutical research. The aim of this study was to use lipidomics to identify a battery of plasma metabolite molecules that could predict AD patients from controls. We performed a comprehensive untargeted lipidomic analysis, using ultra-performance liquid chromatography/mass spectrometry on plasma samples from 35 AD patients, 40 elderly controls and 48 individuals with mild cognitive impairment (MCI) and used multivariate analysis methods to identify metabolites associated with AD status. A combination of 10 metabolites could discriminate AD patients from controls with 79.2% accuracy (81.8% sensitivity, 76.9% specificity and an area under curve of 0.792) in a novel test set. Six of the metabolites were identified as long chain cholesteryl esters (ChEs) and were reduced in AD (ChE 32:0, odds ratio (OR)=0.237, 95% confidence interval (CI)=0.10-0.48, P=4.19E-04; ChE 34:0, OR=0.152, 95% CI=0.05-0.37, P=2.90E-04; ChE 34:6, OR=0.126, 95% CI=0.03-0.35, P=5.40E-04; ChE 32:4, OR=0.056, 95% CI=0.01-0.24, P=6.56E-04 and ChE 33:6, OR=0.205, 95% CI=0.06-0.50, P=2.21E-03, per (log2) metabolite unit). The levels of these metabolites followed the trend control>MCI>AD. We, additionally, found no association between cholesterol, the precursor of ChE and AD. This study identified new ChE molecules, involved in cholesterol metabolism, implicated in AD, which may help identify new therapeutic targets; although, these findings need to be replicated in larger well-phenotyped cohorts.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseBiomarkersCase-Control StudiesCholesterol EstersChromatography, LiquidCognitive DysfunctionFemaleHumansMaleMass SpectrometryMultivariate AnalysisSensitivity and SpecificityBiomarkersCholesterol Esters

Identifiers

PMID25585166
PMCPMC4312824
OpenAlexW2061950854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.