ArticleInternational journal of molecular sciences2015
Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Relationship Between PTBP1 and Pancreatic Cancer Based on microRNA and Behavior During TYMS-Mediated Carcinogenesis.Cancer science · 2026Article
- MicroRNA Profile of Human Small Intestinal Tumors Compared to Colorectal Tumors.Journal of clinical medicine · 2022Article
- Induced miR-31 by 5-fluorouracil exposure contributes to the resistance in colorectal tumors.Cancer science · 2019Article
- Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs.Medical molecular morphology · 2018Article
- Circular RNAs function as competing endogenous RNAs in multiple types of cancer.Oncology letters · 2018Article
- Review
- MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells.Oncotarget · 2017Article
- Circular RNAs: Biogenesis, Function, and a Role as Possible Cancer Biomarkers.International journal of genomics · 2017Review
- MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6.World journal of gastrointestinal oncology · 2016Article
- PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors.Oncotarget · 2016Article
- Circular RNAs as potential biomarkers for cancer diagnosis and therapy.American journal of cancer research · 2016Review
- Clinical Potential of microRNA-7 in Cancer.Journal of clinical medicine · 2015Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We examined the expression of onco-related miRNAs in 131 sporadic exophytic adenomas or early cancers and in 52 sporadic flat elevated adenomas or early cancers to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. The expression levels of miR-143, -145, and -34a were significantly reduced in most of the exophytic tumors compared with those in the flat elevated ones. In type 2 cancers, the miRNA expression profile was very similar to that of the exophytic tumors. The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas. In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process. These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.
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