ArticleMolecular endocrinology (Baltimore, Md.)2015
IGFs mediate the action of LH on oocyte maturation in zebrafish.
Article in Molecular endocrinology (Baltimore, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 91 citations in OpenAlex.
- The Role of Neurohypophysial Hormones in the Endocrine and Paracrine Control of Gametogenesis in Fish.Cells · 2025Review
- The Potential Role of Gonadotropic Hormones and Their Receptors in Sex Differentiation of Nile Tilapia,International journal of molecular sciences · 2025Article
- Integrated lncRNA and mRNA Transcriptome Analyses of IGF1 and IGF2 Stimulated Ovaries Reveal Genes and Pathways Potentially Associated with Ovarian Development and Oocyte Maturation in Golden Pompano (Animals : an open access journal from MDPI · 2025Article
- Identification of Insulin-like Growth Factor (IGF) Family Genes in the Golden Pompano,International journal of molecular sciences · 2024Article
- Alterations in Gene Expression and the Fatty Acid Profile Impact but Do Not Compromise the In Vitro Maturation of Zebrafish (Animals : an open access journal from MDPI · 2023Article
- Comparative Transcriptome Analysis Reveals the Effect ofAnimals : an open access journal from MDPI · 2023Article
- Delayed First Feeding Chronically Impairs Larval Fish Growth Performance, Hepatic Lipid Metabolism, and Visceral Lipid Deposition at the Mouth-Opening Stage.Marine biotechnology (New York, N.Y.) · 2023Article
- Role of insulin-like growth factor 1 (IGF1) in the regulation of mitochondrial bioenergetics in zebrafish oocytes: lessons fromFrontiers in cell and developmental biology · 2023Article
- Article
- Analysis of circRNA and miRNA expression profiles in IGF3-induced ovarian maturation in spotted scat (Frontiers in endocrinology · 2022Article
- Improving the sexual activity and reproduction of female zebrafish with high testosterone levels.Scientific reports · 2021Article
- Insulin-like growth factors 1 and 2 regulate gene expression and enzymatic activity ofHeliyon · 2020Article
- Roles of insulin-like growth factor II in regulating female reproductive physiology.Science China. Life sciences · 2020Review
- Involvement and expression of growth hormone/insulin-like growth factor member mRNAs in the ovarian development of turbot (Scophthalmus maximus).Fish physiology and biochemistry · 2019Article
- Long noncoding RNA and mRNA expression profiles following igf3 knockdown in common carp, Cyprinus carpio.Scientific data · 2019Article
- Molecular characterization and expression profiles of insulin-like growth factors in yellowtail kingfish (Seriola lalandi) during embryonic development.Fish physiology and biochemistry · 2019Article
- Expression patterns and immunolocalisation of IGF-I and IGF-II in male and female gonads of the Neotropical characid fish Astyanax fasciatus.Fish physiology and biochemistry · 2019Article
- Article
- Growth Hormone Overexpression Disrupts Reproductive Status Through Actions on Leptin.Frontiers in endocrinology · 2018Article
- Transcriptomic Analysis for Differentially Expressed Genes in Ovarian Follicle Activation in the Zebrafish.Frontiers in endocrinology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LH signaling is required for oocyte maturation in fish and other vertebrates. However, the downstream factors mediating LH signaling are largely unexplored in fish. In this study, we investigated whether IGFs could mediate LH action on oocyte maturation in zebrafish. Our results show that all igfs, including igf1, igf2a, igf2b, and igf3, are dynamically expressed during folliculogenesis, with the expression of igf3 reaching its maximal level in full grown stage follicles. The expression of igfs is regulated by LH through a cAMP pathway in intact follicles as well as in primary cultured follicular cells, with igf3 expression being the most sensitive to human chorionic gonadotropin (hCG) treatment. Moreover, recombinant zebrafish IGF-2a, IGF-2b, and IGF-3 proteins significantly enhanced oocyte maturation via IGF-1 receptors (IGF-1rs), with IGF-3 exhibiting the most potent stimulatory action on oocyte maturation. Furthermore, we have demonstrated that IGF-3 or hCG treatment could stimulate IGF-1rs phosphorylation, and hCG-induced oocyte maturation could be attenuated by IGF-1r inhibitors as well as by an anti-IGF-3 antiserum in vitro and in vivo, indicating that the IGF system especially IGF-3 plays a crucial role in mediating LH action on oocyte maturation. In addition, igf3 expression is significantly attenuated in LH β-subunit (lhb) mutant zebrafish and treatment with recombinant IGF-3 could partially rescue the oocyte maturation defects of the lhb mutants in vitro and in vivo. Collectively, our results clearly demonstrated that IGFs, particularly the gonad-specific IGF-3, act as important mediators of LH action on oocyte maturation in zebrafish.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.