Evidence map›Paper›PMID 25584327›Full record

ArticleJournal of clinical and diagnostic research : JCDR2014

Lipid profile and metabolic syndrome status in patients with oral lichen planus, oral lichenoid reaction and healthy individuals attending a dental college in northern India - a descriptive study.

Bhuvana Krishnamoorthy, Suma Gn, Mamatha N S, Sowbhagya M B, Komali Garlapati

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  7. Review
  8. Article
  9. Metabolic Derangements in Lichen Planus - A Case Control Study.Journal of clinical and diagnostic research : JCDR · 2016
    Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bhuvana KrishnamoorthyAssociate Professor, Department of Oral Medicine and Radiology, ITS-Centre of Dental Sciences and Research , Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India .
Suma GnProfessor and Head, Department of Oral Medicine and Radiology, ITS-Centre of Dental Sciences and Research , Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India .
Mamatha N SProfessor, Department of Oral and Maxillofacial Surgery, Rajarajeshwari Dental College , Ramohalli Cross, Kumbalogodu, Mysore road, Bangalore, India .
Sowbhagya M BReader, Department of Oral Medicine and Radiology, Rajarajeshwari Dental College , Ramohalli Cross, Kumbalogodu, Mysore road, Bangalore, India .
Komali GarlapatiProfessor, Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Cenntre , Kamalanagar, Hyderabad, India .
Kothiwal Dental College and Research Centre · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic inflammation causes disturbances in the lipid metabolism. When this dyslipidemia becomes prolonged it increases the risk of cardiovascular disease. Recent literature reveals similar dyslipidemia in patients with lichen planus. However, the results were not compared with lichenoid reactions.

objectiveThe aim of this study was to profile the lipid levels and metabolic syndrome status in patients with oral lichen planus (OLP), oral lichenoid reactions (OLR) and healthy individuals in order to evaluate their respective cardiovascular risk. MATERIALS AND

methodsThis case-control descriptive study included 32 adults from the OPD visiting the Department of Oral Medicine, 18 with either oral lichen planus or oral lichenoid reactions and 14 age and sex matched healthy controls. Ethical clearance and informed consent were obtained. Their lipid levels, body mass index and metabolic syndrome status were evaluated. Statistical analyses were performed with the SPSS version 16.0 software.P≥0.05 was considered significant.

resultsThe key findings of this study were a) increased levels of S.cholesterol and LDL-C in OLP and OLR patients when compared to normal healthy individuals b) significantly higher S.triglyceride and VLDL in OLP when compared to OLR and c) lower HDL-C levels in OLP when compared to OLR. 2(18%) patients with OLP and 3(50%) with OLR were found to have high BMI suggestive of obesity whereas none of the normal individuals were obese.

conclusionThere may be an association between chronic inflammation and dyslipidemia that increases the risk for cardiovascular disease. OLP and OLR patients have increased serum cholesterol and LDL-C when compared to normal adults. Further research on lipid levels in OLR are required to establish the findings of this study.

Indexed as

DyslipidemiaLipid profileMetabolic syndrome statusOral lichenoid reactionOral lichen planus

Identifiers

PMID25584327
PMCPMC4290339
OpenAlexW2318957845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.