Evidence map›Paper›PMID 25584301›Full record

ArticleJournal of clinical and diagnostic research : JCDR2014

Efficacy of rebamipide and levamisole in the treatment of patients with recurrent aphthous ulcer - a comparative study.

Parvathi Devi M K, Ramesh D N S V, Shrinivas Koppal, Amit R Byatnal, Thriveni Rukmangada, Aditi A Byatnal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Management of Recurrent Aphthous Stomatitis: An Indian Expert Consensus.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  6. Evaluation of 5% Amlexenox Oral Paste and Rebamipide Tablets in Treatment of Recurrent Apthous Stomatitis and Comparison with Dologel CT.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  7. Review
  8. Article
  9. Microarray analysis of potential genes in the pathogenesis of recurrent oral ulcer.International journal of clinical and experimental pathology · 2015
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Parvathi Devi M KReader, Department of Oral Medicine and Radiology, AMES Dental College and Hospital , Raichur, Karnataka, India .
Ramesh D N S VProfessor, Department of Oral Medicine and Radiology, Pulla Reddy Dental College and Hospital , Kurnool, Andhrapradesh, India .
Shrinivas KoppalProfessor, Department of Oral Medicine and Radiology, AMES Dental College and Hospital , Raichur, Karnataka, India .
Amit R ByatnalAssistant Professor, Department of Oral Medicine and Radiology, AMES Dental College and Hospital , Raichur, Karnataka, India .
Thriveni RukmangadaProfessor and Head, Department of Oral Medicine and Radiology, AMES Dental College and Hospital , Raichur, Karnataka, India .
Aditi A ByatnalPrivate Consultant, Department of Oral and Maxillofacial Pathology, Hubli, Karnataka, India .
Navodaya Dental College and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledContext (Background): Recurrent aphthous stomatitis is an inflammatory condition of unknown aetiology characterized by painful recurrent, single or multiple ulcerations of the oral mucosa.

aimsTo compare the efficacy of rebamipide, a gastro-protective agent and levamisole, an immunomodulating agent in the treatment of recurrent aphthous stomatitis. MATERIALS AND

methodsHundred patients diagnosed with recurrent aphthous stomatitis were enrolled in the study. Fifty patients were assigned randomly to each of the two treatment groups. After the clinical diagnosis and ulcer measurement, a subjective evaluation of symptoms was done for each subject. Both the drugs were given orally at specified intervals. Ulcer measurements and subjective evaluations were made at day one. STATISTICAL ANALYSIS: Analysis was done using various test like Mann Whitney and t-test. RESULTS AND

conclusionThe overall results showed mean number of episodes whose values were not statistically significant (p=0.43), neither were the mean number of ulcers (p=0.75), or values for mean size of ulcers (p=0.91). However, the overall results suggested that efficacy of rebamipide is almost same as that of the efficacy of previously proved drug levamisole. The current study with a three months follow up, including patients with high scores of pain, aphthae count, ulcer size and frequency of occurrence showed better results in both the study groups. However, rebamipide is suggested to be well tolerated and may therefore be useful in the treatment and prevention of frequently recurrent aphthous ulcers not restricted to Behcet's disease.

Indexed as

Aphthous ulcerBehcet’s diseaseLevamisoleOral ulcerRebamipide

Identifiers

PMID25584301
PMCPMC4290343
OpenAlexW2151748482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.