ArticleBiomicrofluidics2014
A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia.
Article in Biomicrofluidics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Mimicking tumor hypoxia in a glioblastoma-on-a-chip.Materials today. Bio · 2026Article
- Cancer-on-a-chip for precision cancer medicine.Lab on a chip · 2025Review
- The progressive trend of modeling and drug screening systems of breast cancer bone metastasis.Journal of biological engineering · 2024Review
- Breaking the mold: 3D cell cultures reshaping the future of cancer research.Frontiers in cell and developmental biology · 2024Review
- Selecting the appropriate indirect viability assay for 3D paper-based cultures: a data-driven study.The Analyst · 2023Article
- The Applications and Challenges of the Development ofCellular and molecular bioengineering · 2023Review
- Recent Advances of Organ-on-a-Chip in Cancer Modeling Research.Biosensors · 2022Review
- Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis.Cancer communications (London, England) · 2022Review
- Monitoring and modulation of the tumor microenvironment for enhanced cancer modeling.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- A Relatively Small Gradient of Extracellular pH Directs Migration of MDA-MB-231 Cells In Vitro.International journal of molecular sciences · 2020Article
- Metabolic Switching of Tumor Cells under Hypoxic Conditions in a Tumor-on-a-chip Model.Micromachines · 2020Article
- Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors.Lab on a chip · 2020Review
- Microfluidic platform for three-dimensional cell culture under spatiotemporal heterogeneity of oxygen tension.APL bioengineering · 2020Article
- Generating linear oxygen gradients across 3D cell cultures with block-layered oxygen controlled chips (BLOCCs).Analytical methods : advancing methods and applications · 2020Article
- Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor Progression.Biomolecules · 2019Review
- Measuring and regulating oxygen levels in microphysiological systems: design, material, and sensor considerations.The Analyst · 2019Review
- Integrated phosphorescence-based photonic biosensor (iPOB) for monitoring oxygen levels in 3D cell culture systems.Biosensors & bioelectronics · 2019Article
- Differential Oxygenation in Tumor Microenvironment Modulates Macrophage and Cancer Cell Crosstalk: Novel Experimental Setting and Proof of Concept.Frontiers in oncology · 2019Article
- Mixing and delivery of multiple controlled oxygen environments to a single multiwell culture plate.American journal of physiology. Cell physiology · 2018Article
- Applications of tumor chip technology.Lab on a chip · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Metastatic cancer cells must traverse a microenvironment ranging from extremely hypoxic, within the tumor, to highly oxygenated, within the host's vasculature. Tumor hypoxia can be further characterized by regions of both chronic and intermittent hypoxia. We present the design and characterization of a microfluidic device that can simultaneously mimic the oxygenation conditions observed within the tumor and model the cell migration and intravasation processes. This device can generate spatial oxygen gradients of chronic hypoxia and produce dynamically changing hypoxic microenvironments in long-term culture of cancer cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.