ArticleBiomicrofluidics2014
Integration of programmable microfluidics and on-chip fluorescence detection for biosensing applications.
Article in Biomicrofluidics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Microvalve array fabrication using selective PDMS (polydimethylsiloxane) bonding through Perfluorooctyl-trichlorosilane passivation for long-term space exploration.Scientific reports · 2022Article
- A Critical Review on the Sensing, Control, and Manipulation of Single Molecules on Optofluidic Devices.Micromachines · 2022Review
- Article
- Optical trapping assisted label-free and amplification-free detection of SARS-CoV-2 RNAs with an optofluidic nanopore sensor.Biosensors & bioelectronics · 2021Article
- Toward the Development of Rapid, Specific, and Sensitive Microfluidic Sensors: A Comprehensive Device Blueprint.JACS Au · 2021Review
- Recent advances in integrated solid-state nanopore sensors.Lab on a chip · 2021Review
- High-Throughput Cell Concentration Using A Piezoelectric Pump in Closed-Loop Viscoelastic Microfluidics.Micromachines · 2021Article
- Ultrasensitive detection of SARS-CoV-2 RNA and antigen using single-molecule optofluidic chip.APL photonics · 2021Article
- Optofluidic multiplex detection of single SARS-CoV-2 and influenza A antigens using a novel bright fluorescent probe assay.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- 7X multiplexed, optofluidic detection of nucleic acids for antibiotic-resistance bacterial screening.Optics express · 2020Article
- Integration of sample preparation and analysis into an optofluidic chip for multi-target disease detection.Lab on a chip · 2018Article
- Multi-channel velocity multiplexing of single virus detection on an optofluidic chip.Optics letters · 2018Article
- Scalable Spatial-Spectral Multiplexing of Single-Virus Detection Using Multimode Interference Waveguides.Scientific reports · 2017Article
- Optofluidic bioanalysis: fundamentals and applications.Nanophotonics (Berlin, Germany) · 2017Article
- Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of Ebola virus.Biosensors & bioelectronics · 2017Article
- On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood.Biomicrofluidics · 2016Article
- Single-virus analysis through chip-based optical detection.Bioanalysis · 2016Article
- Liquid Core ARROW Waveguides: A Promising Photonic Structure for Integrated Optofluidic Microsensors.Micromachines · 2016Review
- A multiplexed immunoaggregation biomarker assay using a two-stage micro resistive pulse sensor.Biomicrofluidics · 2016Article
- Evanescent wave fluorescence biosensors: Advances of the last decade.Biosensors & bioelectronics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
We describe the integration of an actively controlled programmable microfluidic sample processor with on-chip optical fluorescence detection to create a single, hybrid sensor system. An array of lifting gate microvalves (automaton) is fabricated with soft lithography, which is reconfigurably joined to a liquid-core, anti-resonant reflecting optical waveguide (ARROW) silicon chip fabricated with conventional microfabrication. In the automaton, various sample handling steps such as mixing, transporting, splitting, isolating, and storing are achieved rapidly and precisely to detect viral nucleic acid targets, while the optofluidic chip provides single particle detection sensitivity using integrated optics. Specifically, an assay for detection of viral nucleic acid targets is implemented. Labeled target nucleic acids are first captured and isolated on magnetic microbeads in the automaton, followed by optical detection of single beads on the ARROW chip. The combination of automated microfluidic sample preparation and highly sensitive optical detection opens possibilities for portable instruments for point-of-use analysis of minute, low concentration biological samples.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.