Evidence map›Paper›PMID 25584097›Full record

ReviewJournal of clinical medicine research2015

Left ventricular diastolic function in hypertension: methodological considerations and clinical implications.

Pasquale Palmiero, Annapaola Zito, Maria Maiello, Matteo Cameli, Pietro Amedeo Modesti, Maria Lorenza Muiesan, Salvatore Novo, Pier Sergio Saba, Pietro Scicchitano, Roberto Pedrinelli and 1 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of clinical medicine research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07735130 (Angiotensin Receptor Blockade In Patients After Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis With Left Ventricular Hypertrophy), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07735130 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Angiotensin Receptor Blockade In Patients After Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis With Left Ventricular Hypertrophy (ARBITAR) Trial

TypeinterventionalSponsorSeoul National University HospitalRan2026 to 2030Enrolled632ConditionsTranscatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy, Severe Aortic StenosisArmsAngiotensin Receptor Blocker (ARB)
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pasquale PalmieroASL Department of Cardiology, Brindisi District, Italy.
Annapaola ZitoCardiovascular Disease Section, Department of Emergency and Organ Transplantation, University of Bari, Italy.
Maria MaielloASL Department of Cardiology, Brindisi District, Italy.
Matteo CameliDepartment of Cardiovascular Diseases, University of Siena, Italy.
Pietro Amedeo ModestiDepartment of Clinical and Experimental Medicine, University of Florence, Florence, Italy.
Maria Lorenza MuiesanClinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Salvatore NovoDepartment of Internal Medicine and Cardiovascular Diseases, Palermo, Italy.
Pier Sergio SabaCardiologia, Azienda Ospedaliero-Universitaria di Sassari, Italy.
Pietro ScicchitanoCardiovascular Disease Section, Department of Emergency and Organ Transplantation, University of Bari, Italy.
Roberto PedrinelliDipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, Universita di Pisa, Pisa, Italy.
Marco Matteo CicconeCardiovascular Disease Section, Department of Emergency and Organ Transplantation, University of Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The assessment of left ventricular (LV) diastolic function should be an integral part of a routine examination of hypertensive patient; indeed when LV diastolic function is impaired, it is possible to have heart failure even with preserved LV ejection fraction. Left ventricular diastolic dysfunction (LVDD) occurs frequently and is associated to heart disease. Doppler echocardiography is the best tool for early LVDD diagnosis. Hypertension affects LV relaxation and when left ventricular hypertrophy (LVH) occurs, it decreases compliance too, so it is important to calculate Doppler echocardiography parameters, for diastolic function evaluation, in all hypertensive patients. The purpose of our review was to discuss about the strong relationship between LVDD and hypertension, and their relationship with LV systolic function. Furthermore, we aimed to assess the relationship between the arterial stiffness and LV structure and function in hypertensive patients.

Indexed as

Diastolic dysfunctionDiastolic functionHypertensionLeft ventricular

Identifiers

PMID25584097
PMCPMC4285058

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.