ArticleDiabetology & metabolic syndrome2014
Parent-offspring association of metabolic syndrome in the Framingham Heart Study.
Article in Diabetology & metabolic syndrome, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolic Syndrome in Offspring of Parents with Metabolic Syndrome: A Meta-Analysis.Obesity facts · 2021Pooled it
- Insights Into Cardiovascular Disease in Women From the Framingham Heart Study.JACC. Advances · 2026Article
- Familial Associations of Metabolic Syndrome and Its Interrelated Traits in Southwestern Indigenous Americans.The Journal of clinical endocrinology and metabolism · 2025Article
- Parent-Offspring Associations of Ideal Cardiovascular Health Metrics: Findings From the 2014 to 2021 Korea National Health and Nutrition Examination Survey.Journal of the American Heart Association · 2024Article
- Parental metabolic syndrome and elevated liver transaminases are risk factors for offspring, even in children and adolescents with a normal body mass index.Frontiers in nutrition · 2023Article
- Metabolic syndrome and male fertility disorders: Is there a causal link?Reviews in endocrine & metabolic disorders · 2021Review
- Longitudinal association between body mass index and physical activity among adolescents with different parental risk: a parallel latent growth curve modeling approach.The international journal of behavioral nutrition and physical activity · 2020Article
- Association between Parent's Metabolic Syndrome and 12- to18-Year-Old Offspring's Overweight: Results from the Korea National Health and Nutrition Examination Survey (K-NHANES) 2009-2016.International journal of endocrinology · 2020Article
- Effects of a Healthy Lifestyle Education on the Incidence of Metabolic Syndrome in Children during a 13-Year Follow-up.International journal of behavioral medicine · 2018Article
- Invited Commentary: The Framingham Offspring Study-A Pioneering Investigation Into Familial Aggregation of Cardiovascular Risk.American journal of epidemiology · 2017Article
- Weight Gain Trajectories Associated With Elevated C-Reactive Protein Levels in Chinese Adults.Journal of the American Heart Association · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundMetabolic syndrome (MetS) is a clustering of five metabolic risk factors including abdominal obesity, elevated blood pressure, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), and impaired fasting glucose. Few studies have fully reported the strength of clustering of these risk factors in a parent-offspring relationship. This analysis describes the associations between parents and their adult offspring in regard to MetS. It also estimates the association between each risk factor in parents and the presence of MetS in their offspring.
methodsWe analyzed data for 1193 offspring (565 sons, and 628 daughters) from the Framingham Offspring Study who attended examinations 5, 6, and 7. Information about their parents was collected from examinations 13, 14 and 15 of the Framingham Original Cohort study. We used pedigree file to combine parental and offspring's data. Participants were classified as having the MetS according to the Adult Treatment Panel III criteria. Analyses were conducted separately for mothers and fathers. Logistic regression was used to estimate the associations.
resultsAfter adjusting for age, education, smoking, alcohol consumption and physical activity level of offspring, no significant association was found between father's and their offspring's MetS. Mother's MetS was significantly and positively associated with their daughter's MetS (adjusted odds ratio or adj OR: 1.63; 95% confidence Interval, CI:1.02-2.61), but not with their sons' MetS. When analyzed by individual components, maternal impaired glucose (adj OR: 2.03; 95% CI: 1.02- 9.31), abdominal obesity (adj OR: 1.56; 95% CI: 0.98- 2.55) and low HDL-C (adj OR: 2.12; 95% CI: 1.36-3.32) were associated daughter's MetS. Maternal low HDL-C and raised total cholesterol showed marginal association with son's MetS. For fathers, only impaired glucose (adj OR: 4.91; 95% CI: 2.07- 11.68) was associated with their daughter's MetS.
conclusionsUsing the data from Framingham Heart Study, we demonstrate differential association of MetS and its components between parents and offspring. Mother's MetS was strongly related with daughter's MetS, but the association was inconsistent with son's MetS. No association was found between father's MetS and offspring's Mets. These results provide evidence that daughters with mother's MetS are in higher risk than daughters or sons with father's MetS.
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