ArticleJournal of bacteriology2015
The formation of Streptococcus mutans persisters induced by the quorum-sensing peptide pheromone is affected by the LexA regulator.
Article in Journal of bacteriology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Quorum sensing rewires membrane vesicle protein cargo to promote antibiotic persistence inJournal of bacteriology · 2026Article
- AJournal of bacteriology · 2026Review
- Dissecting microbial communities with single-cell transcriptome analysis.Science (New York, N.Y.) · 2025Review
- Article
- Glucose Supplementation Enhances the Bactericidal Effect of Penicillin and Gentamicin onAntibiotics (Basel, Switzerland) · 2025Article
- Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation.Frontiers in microbiology · 2025Review
- Transcriptome Analysis ofGenes · 2023Article
- Quorum sensing as a mechanism to harness the wisdom of the crowds.Nature communications · 2023Article
- Growth with Commensal Streptococci AltersJournal of dental research · 2023Article
- Article
- Review
- Identification of Biomarkers for Systemic Distribution of Nanovesicles FromFrontiers in immunology · 2021Article
- A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery.Antibiotics (Basel, Switzerland) · 2020Article
- Tolerance and Persister Formation in Oral Streptococci.Antibiotics (Basel, Switzerland) · 2020Article
- ResumptiveFrontiers in microbiology · 2019Article
- Threshold regulation and stochasticity from the MecA/ClpCP proteolytic system in Streptococcus mutans competence.Molecular microbiology · 2018Article
- Quaternary ammonium-induced multidrug tolerant Streptococcus mutans persisters elevate cariogenic virulence in vitro.International journal of oral science · 2017Article
- Formation of persisters in Streptococcus mutans biofilms induced by antibacterial dental monomer.Journal of materials science. Materials in medicine · 2017Article
- Antibacterial and Antibiofilm Activities of a Novel Synthetic Cyclic Lipopeptide against Cariogenic Streptococcus mutans UA159.Antimicrobial agents and chemotherapy · 2017Article
- Transcriptional Repressor PtvR Regulates Phenotypic Tolerance to Vancomycin in Streptococcus pneumoniae.Journal of bacteriology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The presence of multidrug-tolerant persister cells within microbial populations has been implicated in the resiliency of bacterial survival against antibiotic treatments and is a major contributing factor in chronic infections. The mechanisms by which these phenotypic variants are formed have been linked to stress response pathways in various bacterial species, but many of these mechanisms remain unclear. We have previously shown that in the cariogenic organism Streptococcus mutans, the quorum-sensing peptide CSP (competence-stimulating peptide) pheromone was a stress-inducible alarmone that triggered an increased formation of multidrug-tolerant persisters. In this study, we characterized SMU.2027, a CSP-inducible gene encoding a LexA ortholog. We showed that in addition to exogenous CSP exposure, stressors, including heat shock, oxidative stress, and ofloxacin antibiotic, were capable of triggering expression of lexA in an autoregulatory manner akin to that of LexA-like transcriptional regulators. We demonstrated the role of LexA and its importance in regulating tolerance toward DNA damage in a noncanonical SOS mechanism. We showed its involvement and regulatory role in the formation of persisters induced by the CSP-ComDE quorum-sensing regulatory system. We further identified key genes involved in sugar and amino acid metabolism, the clustered regularly interspaced short palindromic repeat (CRISPR) system, and autolysin from transcriptomic analyses that contribute to the formation of quorum-sensing-induced persister cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.