Evidence map›Paper›PMID 25583719›Full record

ArticleAntimicrobial agents and chemotherapy2015

Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil.

Milena Dropa, Barbara Ghiglione, Maria Helena Matté, Livia Carminato Balsalobre, Nilton Lincopan, Glavur Rogério Matté, Gabriel Gutkind, Pablo Power

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Antimicrobial resistance in Enterobacteriaceae in Brazil: focus on β-lactams and polymyxins.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Milena DropaSchool of Public Health, University of São Paulo, São Paulo, Brazil milenadropa@gmail.com.
Barbara GhiglioneSchool of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
Maria Helena MattéSchool of Public Health, University of São Paulo, São Paulo, Brazil.
Livia Carminato BalsalobreSchool of Public Health, University of São Paulo, São Paulo, Brazil.
Nilton LincopanInstitute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Glavur Rogério MattéSchool of Public Health, University of São Paulo, São Paulo, Brazil.
Gabriel GutkindSchool of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
Pablo PowerSchool of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CTX-M-131 is a natural Asp240Gly variant from the CTX-M-2 group detected in a Providencia rettgeri clinical strain from Brazil. Molecular analysis showed that blaCTX-M-131 was inserted in a complex class 1 integron harbored by a 112-kb plasmid, which has not been previously described as a platform for CTX-M-encoding genes with the Asp240Gly mutation. Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime.

Indexed as

Anti-Bacterial Agentsbeta-LactamasesBrazilCeftazidimeIntegrinsKineticsPlasmidsProvidenciaAnti-Bacterial Agentsbeta-lactamase CTX-2beta-LactamasesCeftazidimeIntegrins

Identifiers

PMID25583719
PMCPMC4325771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.