Trial reportIntensive care medicine2015
Protocolized fluid therapy in brain-dead donors: the multicenter randomized MOnIToR trial.
Trial report in Intensive care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00987714 (Monitoring Organ Donors to Increase Transplantation Results), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Monitoring Organ Donors to Increase Transplantation Results
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Donor heart selection: Evidence-based guidelines for providers.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Guideline
- Cholinergic Improvement of Low-Flow Segmental Aqueous Humor Outflow in Humans.Ophthalmology science · 2026Article
- Optimizing recovery of marginal donor hearts with low ejection fraction: A national retrospective study from Switzerland.JHLT open · 2026Article
- Contemporary evidence to inform management of deceased potential thoracic organ donors after brain death.JHLT open · 2026Article
- Management of the brain-dead donor in the intensive care unit.Intensive care medicine · 2024Article
- Retinal electrophysiologic response to IOP elevation in living human eyes.Experimental eye research · 2023Article
- Specialized Donor Care Facility Model and Advances in Management of Thoracic Organ Donors.The Annals of thoracic surgery · 2022Review
- Brazilian guidelines for the management of brain-dead potential organ donors. The task force of the AMIB, ABTO, BRICNet, and the General Coordination of the National Transplant System.Annals of intensive care · 2020Article
- Expedited organ donation in Victoria, Australia: donor characteristics and donation outcomes.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2020Article
- Renal Procurement: Techniques for Optimizing the Quality of the Graft in the Cadaveric Setting.Current urology reports · 2020Review
- Intraoperative management of brain-dead organ donors by anesthesiologists during an organ procurement procedure: results from a French survey.BMC anesthesiology · 2019Article
- Management of the brain-dead donor in the ICU: general and specific therapy to improve transplantable organ quality.Intensive care medicine · 2019Review
- Donor biomarkers as predictors of organ use and recipient survival after neurologically deceased donor organ transplantation.Journal of critical care · 2018Article
- Evaluation and Management of the Potential Lung Donor.Clinics in chest medicine · 2017Review
- ICU Management of the Potential Organ Donor: State of the Art.Current neurology and neuroscience reports · 2016Review
- Organ-Protective Intensive Care in Organ Donors.Deutsches Arzteblatt international · 2016Review
- In support of 'usual' perioperative care.British journal of anaesthesia · 2016Article
- Organ donation in adults: a critical care perspective.Intensive care medicine · 2016Review
- Improving donor management and transplantation success: more research is needed.Intensive care medicine · 2015Article
- Brazilian guidelines for the management of brain-dead potential organ donors. The task force of the Associação de Medicina Intensiva Brasileira, Associação Brasileira de Transplantes de Órgãos, Brazilian Research in Critical Care Network, and the General Coordination of the National Transplant System.Revista Brasileira de terapia intensivaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundCritical shortages of organs for transplantation jeopardize many lives. Observational data suggest that better fluid management for deceased organ donors could increase organ recovery. We conducted the first large multicenter randomized trial in brain-dead donors to determine whether protocolized fluid therapy increases the number of organs transplanted.
methodsWe randomly assigned donors to either protocolized or usual care in eight organ procurement organizations. A "protocol-guided fluid therapy" algorithm targeting the cardiac index, mean arterial pressure and pulse pressure variation was used. Our primary outcome was the number of organs transplanted per donor, and our primary analysis was intention to treat. Secondary analyses included: (1) modified intention to treat where only subjects able to receive the intervention were included and (2) 12-month survival in transplant recipients. The study was stopped early.
resultsWe enrolled 556 donors: 279 protocolized care and 277 usual care. Groups had similar characteristics at baseline. The study protocol could be implemented in 76 % of subjects randomized to the intervention. There was no significant difference in mean number of organs transplanted per donor: 3.39 organs per donor (95 % CI 3.14-3.63) with protocolized care compared to 3.29 usual care (95 % CI 3.04-3.54; mean difference, 0.1, 95 % CI -0.25 to 0.45; p = 0.56). In modified intention-to-treat analysis the mean number of organs increased (3.52 organs per donor, 95 % CI 3.23-3.8), but not statistically significantly (mean difference, 0.23, 95 % CI -0.15 to 0.61; p = 0.23). Among the 1,430 recipients of organs from study subjects with data available, 56 deaths (7.8 %) occurred in the protocolized care arm and 56 (7.9 %) in the usual care arm in the first year (hazard ratio: 0.97, p = 0.86).
conclusionsIn brain-dead organ donors, protocol-guided fluid therapy compared to usual care may not increase the number of organs transplanted per donor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.