Evidence map›Paper›PMID 25583558›Full record

Trial reportGastrointestinal endoscopy2015

Detection rates of premalignant polyps during screening colonoscopy: time to revise quality standards?

William A Ross, Selvi Thirumurthi, Patrick M Lynch, Asif Rashid, Mala Pande, Mehnaz A Shafi, Jeffrey H Lee, Gottumukkala S Raju

Abstract readClinical Trial
In one paragraph

Trial report in Gastrointestinal endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Quality indicators for colonoscopy.Gastrointestinal endoscopy · 2024
    Guideline
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Quality Indicators for Colonoscopy.The American journal of gastroenterology · 2024
    Article
  7. Key quality indicators in colonoscopy.Gastroenterology report · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Observational
  15. Article
  16. Standards of diagnostic colonoscopy for early-stage neoplasia: Recommendations by an Asian private group.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

William A RossDepartment of Gastroenterology, Hepatology, and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA.
Selvi ThirumurthiDepartment of Gastroenterology, Hepatology, and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA.
Patrick M LynchDepartment of Gastroenterology, Hepatology, and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA.
Asif RashidDepartment of Pathology, MD Anderson Cancer Center, Houston, Texas, USA.
Mala PandeDepartment of Gastroenterology, Hepatology, and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA.
Mehnaz A ShafiDepartment of Gastroenterology, Hepatology, and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA.
Jeffrey H LeeDepartment of Gastroenterology, Hepatology, and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA.
Gottumukkala S RajuDepartment of Gastroenterology, Hepatology, and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA.

Funding

Susceptibility Markers for a Breast-Colon Cancer PhenotypeK07CA160753 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PANDE, MALA · 2012 to 2016
$603k
NCI NIH HHS K07 CA160753NCI NIH HHS K07CA160753
6 · The paper itself

Abstract

backgroundStandards for the detection of adenomas during screening colonoscopy are widely used to measure examination quality. No such standards exist for sessile serrated adenomas (SSAs).

objectiveTo measure both the adenoma detection rate (ADR) and SSA detection rate (SSADR) during screening colonoscopy before and after quality improvement/financial incentive measures.

designRetrospective determination of baseline ADR/SSADR by the endoscopist, followed by prospective collection of data after informing physicians of baseline detection rates.

settingTertiary cancer center with a large cancer screening program. PATIENTS: A total of 2833 average-risk colorectal cancer screening patients 50 to 75 years of age undergoing initial colonoscopy. DATA COLLECTION: Electronic medical records for indication and demographics, endoscopy report, and pathology report. MAIN OUTCOME MEASUREMENTS: Detection rates of adenomas and SSAs by sex.

resultsThe overall ADR in male and female patients was 50.6% and 36.6%, respectively. The overall detection rate of advanced adenomas in male and female patients was 12.4% and 6.5%, respectively. The overall SSADR in male and female patients was 10.1% and 7.1%, respectively. In 108 patients (3.8% of entire group), SSAs were the only premalignant lesions found. Detection rates of both types of premalignant polyps improved over time but did not reach statistical significance. LIMITATIONS: Single-center experience with limited sample size and small group of endoscopists.

conclusionADRs far in excess of current standards are achievable. Cecal withdrawal time is associated with the ADR. Prevalence of SSA rivals that of advanced adenomas and is greater than current medical literature suggests. The combination of monitoring and financial incentives did not result in statistically significant improvement in ADRs.

Indexed as

Quality ImprovementAdenomaAgedColonic PolypsColonoscopyColorectal NeoplasmsEarly Detection of CancerFemaleHumansLogistic ModelsMaleMiddle AgedProspective StudiesRetrospective Studies

Identifiers

PMID25583558
PMCPMC4340745

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.