ArticleProceedings of the National Academy of Sciences of the United States of America2015
Hierarchical sparse coding in the sensory system of Caenorhabditis elegans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Article
- Starvation transforms signal encoding ineLife · 2026Article
- Article
- Deciphering the regulatory mechanism of neural behavioral decisions through biogenic amine-mediated modulation of neural circuits inFrontiers in systems neuroscience · 2026Review
- Evolution of lateralized gustation in nematodes.eLife · 2025Article
- Aberrant Positions of the Chemosensory Neurons in the Neurotransmitter-Release MutantInternational journal of molecular sciences · 2024Article
- Intricate response dynamics enhances stimulus discrimination in the resource-limited C. elegans chemosensory system.BMC biology · 2024Article
- Neuron cilia restrain glial KCC-3 to a microdomain to regulate multisensory processing.Cell reports · 2024Article
- Sensory integration of food availability and population density during the diapause exit decision involves insulin-like signaling inbioRxiv : the preprint server for biology · 2024Article
- Chemosensory detection of polyamine metabolites guidesScience advances · 2024Article
- Neuroendocrine gene expression coupling of interoceptive bacterial food cues to foraging behavior ofeLife · 2024Article
- See Elegans: Simple-to-use, accurate, and automatic 3D detection of neural activity from densely packed neurons.PloS one · 2024Article
- Neuroendocrine Gene Expression Coupling of Interoceptive Bacterial Food Cues to Foraging Behavior ofbioRxiv : the preprint server for biology · 2023Article
- An expanded GCaMP reporter toolkit for functional imaging in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- Inheritance of associative memories and acquired cellular changes in C. elegans.Nature communications · 2023Article
- The conserved endocannabinoid anandamide modulates olfactory sensitivity to induce hedonic feeding in C. elegans.Current biology : CB · 2023Article
- Article
- The nematode wormeLife · 2023Article
- An expanded GCaMP reporter toolkit for functional imaging inbioRxiv : the preprint server for biology · 2023Article
- Functional imaging and quantification of multineuronal olfactory responses inScience advances · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Animals with compact sensory systems face an encoding problem where a small number of sensory neurons are required to encode information about its surrounding complex environment. Using Caenorhabditis elegans worms as a model, we ask how chemical stimuli are encoded by a small and highly connected sensory system. We first generated a comprehensive library of transgenic worms where each animal expresses a genetically encoded calcium indicator in individual sensory neurons. This library includes the vast majority of the sensory system in C. elegans. Imaging from individual sensory neurons while subjecting the worms to various stimuli allowed us to compile a comprehensive functional map of the sensory system at single neuron resolution. The functional map reveals that despite the dense wiring, chemosensory neurons represent the environment using sparse codes. Moreover, although anatomically closely connected, chemo- and mechano-sensory neurons are functionally segregated. In addition, the code is hierarchical, where few neurons participate in encoding multiple cues, whereas other sensory neurons are stimulus specific. This encoding strategy may have evolved to mitigate the constraints of a compact sensory system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.