ArticleTropical medicine & international health : TM & IH2015
Identifying locations of recent TB transmission in rural Uganda: a multidisciplinary approach.
Article in Tropical medicine & international health : TM & IH, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevention of tuberculosis in household members: estimates of children eligible for treatment.Bulletin of the World Health Organization · 2019Pooled it
- Spatially targeted screening to reduce tuberculosis transmission in high-incidence settings.The Lancet. Infectious diseases · 2019Pooled it
- Methods used in the spatial analysis of tuberculosis epidemiology: a systematic review.BMC medicine · 2018Pooled it
- Article
- Role of casual contact in drug-resistant tuberculosis transmission: a molecular epidemiology study.American journal of respiratory and critical care medicine · 2026Article
- The Role of Community Networks in the Transmission and Persistence ofOpen forum infectious diseases · 2025Article
- Integrating genomic and spatial analyses to describe tuberculosis transmission: a scoping review.The Lancet. Microbe · 2025Article
- Incident Tuberculosis Infection Is Associated With Alcohol Use in Adults in Rural Uganda.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Mobility patterns, activity locations, and TB in Nairobi, Kenya.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2025Article
- Blurring cluster randomized trials and observational studies: Two-Stage TMLE for subsampling, missingness, and few independent units.Biostatistics (Oxford, England) · 2024Article
- Incidence of tuberculous infection in a TB-endemic city.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2024Article
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- Identification of Risk Factors Associated with Tuberculosis in Southwest Iran: A Machine Learning Method.Medical journal of the Islamic Republic of Iran · 2024Article
- Designing community-based strategies to reach non-household contacts of people with tuberculosis in Lusaka, Zambia: a rapid qualitative study among key stakeholders.Frontiers in public health · 2024Article
- Heterogeneity of Mycobacterium tuberculosis Strains Circulating in Panama's Western Region.The American journal of tropical medicine and hygiene · 2023Article
- The Association Between Social Network Characteristics and Tuberculosis Infection Among Adults in 9 Rural Ugandan Communities.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Quantifying Mycobacterium tuberculosis Transmission Dynamics Across Global Settings: A Systematic Analysis.American journal of epidemiology · 2023Article
- Geospatial analysis of reported activity locations to identify sites for tuberculosis screening.Scientific reports · 2022Article
- Excess Risk of Tuberculosis Infection Among Extra-household Contacts of Tuberculosis Cases in an African City.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Community transmission of multidrug-resistant tuberculosis is associated with activity space overlap in Lima, Peru.BMC infectious diseases · 2021Article
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7 authors.
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Abstract
objectivesTargeting high Tuberculosis (TB) transmission sites may offer a novel approach to TB prevention in sub-Saharan Africa. We sought to characterise TB transmission sites in a rural Ugandan township.
methodsWe recruited adults starting TB treatment in Tororo, Uganda, over 1 year. Fifty four TB cases provided names of frequent contacts, sites of residence, health care, work and social activities, and two sputum samples. Mycobacterium tuberculosis (MTB) culture-positive specimens underwent spoligotyping to identify strains with shared genotypes. We visualised TB case social networks, and obtained, mapped and geo-coded global positioning system measures for every location that cases reported frequenting 1 month before treatment. Locations of spatial overlap among genotype-clustered cases were considered potential transmission sites.
resultsSix distinct genotypic clusters were identified involving 21 of 33 (64%) MTB culture-positive, genotyped cases; none shared a home. Although 18 of 54 (33%) TB cases shared social network ties, none of the genotype-clustered cases shared social ties. Using spatial analysis, we identified potential sites of within-cluster TB transmission for five of six genotypic clusters. All sites but one were healthcare and social venues, including sites of drinking, worship and marketplaces. Cases reported spending the largest proportion of pre-treatment person-time (22.4%) at drinking venues.
conclusionsUsing molecular epidemiology, geospatial and social network data from adult TB cases identified at clinics, we quantified person-time spent at high-risk locations across a rural Ugandan community and determined the most likely sites of recent TB transmission to be healthcare and social venues. These sites may not have been identified using contact investigation alone.
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