Evidence map›Paper›PMID 25583167›Full record

ArticleThe Journal of infectious diseases2015

Human Influenza A Virus-Specific CD8+ T-Cell Response Is Long-lived.

Carolien E van de Sandt, Marine L B Hillaire, Martina M Geelhoed-Mieras, Albert D M E Osterhaus, Ron A M Fouchier, Guus F Rimmelzwaan

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. The ageing immune system and its battle with viruses.The Journal of general virology · 2026
    Review
  2. Review
  3. Assessing CD8Clinical & translational immunology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Immune Response to Respiratory Viral Infections.International journal of molecular sciences · 2024
    Review
  8. Review
  9. CD8Nature communications · 2024
    Article
  10. Article
  11. Article
  12. Fighting flu: novel CD8Clinical & translational immunology · 2024
    Review
  13. Article
  14. Review
  15. Identification of HLA-A2 restricted CD8Journal of leukocyte biology · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carolien E van de SandtDepartment of Viroscience, Erasmus Medical Center.
Marine L B HillaireDepartment of Viroscience, Erasmus Medical Center.
Martina M Geelhoed-MierasDepartment of Viroscience, Erasmus Medical Center.
Albert D M E OsterhausDepartment of Viroscience, Erasmus Medical Center ViroClinics Biosciences, Rotterdam, The Netherlands.
Ron A M FouchierDepartment of Viroscience, Erasmus Medical Center.
Guus F RimmelzwaanDepartment of Viroscience, Erasmus Medical Center ViroClinics Biosciences, Rotterdam, The Netherlands.

Funding

NIAID NIH HHS HHSN272201400008CPHS HHS HHSN272201400008C
6 · The paper itself

Abstract

Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.

Indexed as

Immunologic MemoryAdolescentAdultAlphainfluenzavirusCD8-Positive T-LymphocytesFemaleHumansInfluenza, HumanLeukocytes, MononuclearMaleMiddle AgedTime FactorsT-Lymphocytes, CytotoxicYoung AdultCD8+ T cellshumanimmunityinfluenza A viruslongevity

Identifiers

PMID25583167
PMCPMC4542594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.