ArticleEpidemiology and infection2015
Concomitant leptospirosis-hantavirus co-infection in acute patients hospitalized in Sri Lanka: implications for a potentially worldwide underestimated problem.
Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Factors Associated with the Prevalence of Dengue-Leptospirosis Coinfection in Patients Hospitalized for Febrile Syndrome.Tropical medicine and infectious disease · 2026Article
- Lanka virus, a Mus booduga-borne orthohantavirus infection-associated febrile illness in Sri Lanka.PLoS neglected tropical diseases · 2025Article
- Detection of two zoonotic pathogens,One health (Amsterdam, Netherlands) · 2025Article
- Article
- Hantavirus infection in central Sri Lanka - an unusual clinical presentation: a case report.Access microbiology · 2024Article
- Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting.PLoS neglected tropical diseases · 2022Article
- Article
- Exposure of Free-Ranging Wild Animals to ZoonoticAnimals : an open access journal from MDPI · 2021Article
- Hantavirus-Epidemiology and infection · 2021Article
- Leptospiral Infection, Pathogenesis and Its Diagnosis-A Review.Pathogens (Basel, Switzerland) · 2021Review
- Association of Hantavirus Infections and Leptospirosis With the Occurrence of Chronic Kidney Disease of Uncertain Etiology in the North Central Province of Sri Lanka: A Prospective Study With Patients and Healthy Persons.Frontiers in cellular and infection microbiology · 2020Article
- A Case-Control Study of Environmental and Occupational Risks of Leptospirosis in Sri Lanka.EcoHealth · 2019Article
- Review
- Infections and the kidney: a tale from the tropics.Pediatric nephrology (Berlin, Germany) · 2018Review
- Article
- Towards a geocomputational landscape epidemiology: surveillance, modelling, and interventions.GeoJournal · 2017Review
- Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka.BMC infectious diseases · 2016Article
- Molecular diagnostics for human leptospirosis.Current opinion in infectious diseases · 2016Review
- Redefining Gold Standard Testing for Diagnosing Leptospirosis: Further Evidence from a Well-Characterized, Flood-Related Outbreak in Sri Lanka.The American journal of tropical medicine and hygiene · 2016Article
- 'Bedside assessment' of acute hantavirus infections and their possible classification into the spectrum of haemophagocytic syndromes.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two global (re-)emerging zoonoses, leptospirosis and hantavirus infections, are clinically indistinguishable. Thirty-one patients, hospitalized in Sri Lanka for acute severe leptospirosis, were after exclusion of other potentially involved pathogens, prospectively screened with IgM ELISA for both pathogens. Of these, nine (29·0%) were positive for leptospirosis only, one (3·2%) for hantavirus only, seven (22·5%) for both pathogens concomitantly, whereas 13 (41·9%) remained negative for both. Moreover, in a retrospective study of 23 former patients, serologically confirmed for past leptospirosis, six (26·0%) were also positive in two different IgG ELISA hantavirus formats. Surprisingly, European Puumala hantavirus (PUUV) results were constantly higher, although statistically not significantly different, than Asian Hantaan virus (HTNV), suggesting an unexplained cross-reaction, since PUUV is considered absent throughout Asia. Moreover, RT-PCR on all hantavirus IgM ELISA positives was negative. Concomitant leptospirosis-hantavirus infections are probably heavily underestimated worldwide, compromising epidemiological data, therapeutical decisions, and clinical outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.