ArticleNature communications2015
Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- The temporal architecture of the seminiferous epithelial cycle revealed by spatial transcriptomics.Cell · 2026Article
- Deep learning of 777 K bulk transcriptomes reveals human-mouse gene conservation beyond DNA sequence similarity.Communications biology · 2026Article
- Organelle resilience as a comparative blueprint for longevity.EMBO molecular medicine · 2026Review
- Epigenetic characterization of pseudogenes across human tissues.Genome research · 2026Article
- Aging impairs the antiviral defense in Caenorhabditis elegans due to loss of DRH-1/RIG-I deSUMOylation by ULP-4/SENP7.EMBO reports · 2025Article
- Transcriptomic Characterization of Male Formosan Pangolin (Animals : an open access journal from MDPI · 2024Article
- Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals.Nature communications · 2024Article
- Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx.Nature methods · 2024Article
- Quantifying transcriptome diversity: a review.Briefings in functional genomics · 2024Review
- Genic constraint against nonsynonymous variation across the mouse genome.BMC genomics · 2023Article
- Dynamic Spatial-temporal Expression Ratio of X Chromosome to Autosomes but Stable Dosage Compensation in Mammals.Genomics, proteomics & bioinformatics · 2023Article
- HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver.Frontiers in endocrinology · 2023Article
- CLIMB: High-dimensional association detection in large scale genomic data.Nature communications · 2022Article
- Evolution and function of developmentally dynamic pseudogenes in mammals.Genome biology · 2022Article
- Genomic and functional conservation of lncRNAs: lessons from flies.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- Recursive splicing is a rare event in the mouse brain.PloS one · 2022Article
- RBFOX splicing factors contribute to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus.Genome research · 2021Article
- Multiple Lesions Contribute to Infertility in Males Lacking Autoimmune Regulator.The American journal of pathology · 2021Article
- Enhancers with tissue-specific activity are enriched in intronic regions.Genome research · 2021Article
- Distinctive regulatory architectures of germline-active and somatic genes inGenome research · 2020Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
Mice have been a long-standing model for human biology and disease. Here we characterize, by RNA sequencing, the transcriptional profiles of a large and heterogeneous collection of mouse tissues, augmenting the mouse transcriptome with thousands of novel transcript candidates. Comparison with transcriptome profiles in human cell lines reveals substantial conservation of transcriptional programmes, and uncovers a distinct class of genes with levels of expression that have been constrained early in vertebrate evolution. This core set of genes captures a substantial fraction of the transcriptional output of mammalian cells, and participates in basic functional and structural housekeeping processes common to all cell types. Perturbation of these constrained genes is associated with significant phenotypes including embryonic lethality and cancer. Evolutionary constraint in gene expression levels is not reflected in the conservation of the genomic sequences, but is associated with conserved epigenetic marking, as well as with characteristic post-transcriptional regulatory programme, in which sub-cellular localization and alternative splicing play comparatively large roles.
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