ArticleSpinal cord2015
Hyponatremia in spinal cord injury patients: new insight into differentiating between the dilution and depletion forms.
Article in Spinal cord, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 21 citations in OpenAlex.
- Dual receptor therapy with pituitrin for spinal cord injury-induced diabetes insipidus: A propensity-matched retrospective cohort study.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Article
- Construction and validation of a risk prediction model for hyponatremia caused by cervical spinal cord injury.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Mechanisms of hyponatremia and diabetes insipidus after acute spinal cord injury: a critical review.Chinese neurosurgical journal · 2023Review
- Serum glucose/potassium ratio as a clinical risk factor for predicting the severity and prognosis of acute traumatic spinal cord injury.BMC musculoskeletal disorders · 2023Article
- Pearls & Oy-sters: Syndrome of Inappropriate Antidiuretic Hormone Secretion Presenting as Neuromyelitis Optica Spectrum Disorder Flare.Neurology · 2023Article
- Review
- Analysis of risk factors for hyponatremia in patients with acute spinal cord injury: a retrospective single-institution study in Japan.Spinal cord · 2019Observational
- Nutritional blood parameters and nutritional risk screening in patients with spinal cord injury and deep pressure ulcer-a retrospective chart analysis.Spinal cord · 2018Article
- Influenza as a Cause of SIADH Related Hyponatremia: A Case Report.Journal of clinical and diagnostic research : JCDR · 2017Article
- Response to 'Hyponatremia in spinal cord injury patients: new insight into differentiating between the dilution and depletion forms'.Spinal cord · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designThis is a retrospective study.
objectivesThe objectives of this study were to present a new model for differentiating between the dilution and depletion forms of hyponatremia in patients in the postacute phase after spinal cord injury (SCI), and to identify possible etiological factors contributing to hyponatremia in these patients.
settingUniversity Hospital Motol, Prague, Czech Republic.
methodsEighty-seven of 352 patients hospitalized in 2008-2012 in the Spinal Cord Unit were hyponatremic. Seventy-four patients had SNa+=130-135 mmol l(-1) and 13 patients had SNa+ below 130 mmol l(-1). We propose a simple model of an electrolyte solution in which the Na(+) concentration is higher than the Cl(-) concentration, making it possible to compare the effects of dilution and depletion of Na(+) and Cl(-) on the Na(+) concentration. The depletion of Na(+) and Cl(-) leads to a significant increase in the Na(+)/Cl(-) ratio, with the Na(+)-Cl(-) value remaining unchanged. Dilution with water results in a decrease of Na(+)-Cl(-) with the Na(+)/Cl(-) ratio remaining unchanged.
resultsIn patients with SNa+ below 130 mmol l(-1), hyponatremia was consistent with the depletion model in 46% and with the dilution model in 32%. In patients with SNa+ ranging between 130 and 135 mmol l(-1), the respective rates were 34 and 12%.
conclusionExamination of SNa+-SCl- and SNa+/SCl- in patients with SCI could be helpful in considering whether hyponatremia is consistent either with the NaCl dilution model or with the NaCl depletion model. Further studies are needed for more accurate interpretation of the results, particularly with respect to volume and acid-base disorders.
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