ReviewThe journal of spinal cord medicine2015
Electrical stimulation for the treatment of lower urinary tract dysfunction after spinal cord injury.
Review in The journal of spinal cord medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06845904 (Study on Preliminary Safety and Efficacy of Epidural Electrical Stimulation to Manage Lower Urinary Tract Dysfunction After Spinal Cord Injury), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on Preliminary Safety and Efficacy of Epidural Electrical Stimulation to Manage Lower Urinary Tract Dysfunction After Spinal Cord Injury
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of acupuncture therapy plus related rehabilitation therapy for post-stroke urinary incontinence: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Transcutaneous neuromodulation versus oxybutynin for neurogenic detrusor overactivity in persons with spinal cord injury: A randomized, investigator blinded, parallel group, non-inferiority controlled trial.The journal of spinal cord medicine · 2025Trial
- A Pilot Feasibility Trial of Multi-Program Epidural Spinal Cord Stimulation for Bladder Function Recovery in Chronic Spinal Cord Injury.Journal of clinical medicine · 2026Article
- Animal models of spinal cord injury in neuro-urological research.Nature reviews. Urology · 2026Review
- Bladder Responses to Thoracolumbar Epidural Stimulation in Female Urethane-Anesthetized Rats with Graded Contusion Spinal Cord Injuries.Journal of neurotrauma · 2025Article
- The inhibitory effect of intraspinal microstimulation of the sacral spinal cord on nonlinear bladder reflex dynamics in cats.Frontiers in neuroscience · 2025Article
- Clinical efficacy of bladder function training combined with pelvic floor biofeedback electrical stimulation on neurogenic bladder and its impact on urodynamics.Pakistan journal of medical sciences · 2025Article
- An innovative electrical neurostimulation approach to mimic reflexive urination control in spinal cord injury models.Scientific reports · 2024Article
- A wireless, battery-free device for electrical neuromodulation of bladder contractions.Materials today. Bio · 2024Article
- Model-based analysis of the acute effects of transcutaneous magnetic spinal cord stimulation on micturition after spinal cord injury in humans.PLoS computational biology · 2024Article
- Prediction of early bladder outcomes after spinal cord injury: The HALT score.CNS neuroscience & therapeutics · 2024Article
- Trans-Spinal Electrical Stimulation Therapy for Functional Rehabilitation after Spinal Cord Injury: Review.Journal of clinical medicine · 2022Review
- Thoracolumbar epidural stimulation effects on bladder and bowel function in uninjured and chronic transected anesthetized rats.Scientific reports · 2022Article
- HFAC Dose Repetition and Accumulation Leads to Progressively Longer Block Carryover Effect in Rat Sciatic Nerve.Frontiers in neuroscience · 2022Article
- Spinal interneurons of the lower urinary tract circuits.Autonomic neuroscience : basic & clinical · 2021Review
- Meeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research.Journal of neurotrauma · 2021Review
- Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats.Scientific reports · 2021Article
- Feasibility of Real-Time Conditional Sacral Neuromodulation Using Wireless Bladder Pressure Sensor.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021Article
- Intraspinal stimulation with a silicon-based 3D chronic microelectrode array for bladder voiding in cats.Journal of neural engineering · 2020Article
- Recent progress on peripheral neural interface technology towards bioelectronic medicine.Bioelectronic medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Electrical stimulation for bladder control is an alternative to traditional methods of treating neurogenic lower urinary tract dysfunction (NLUTD) resulting from spinal cord injury (SCI). In this review, we systematically discuss the neurophysiology of bladder dysfunction following SCI and the applications of electrical stimulation for bladder control following SCI, spanning from historic clinical approaches to recent pre-clinical studies that offer promising new strategies that may improve the feasibility and success of electrical stimulation therapy in patients with SCI. Electrical stimulation provides a unique opportunity to control bladder function by exploiting neural control mechanisms. Our understanding of the applications and limitations of electrical stimulation for bladder control has improved due to many pre-clinical studies performed in animals and translational clinical studies. Techniques that have emerged as possible opportunities to control bladder function include pudendal nerve stimulation and novel methods of stimulation, such as high frequency nerve block. Further development of novel applications of electrical stimulation will drive progress towards effective therapy for SCI. The optimal solution for restoration of bladder control may encompass a combination of efficient, targeted electrical stimulation, possibly at multiple locations, and pharmacological treatment to enhance symptom control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.