Evidence map›Paper›PMID 25582038›Full record

ReviewTrends in immunology2015

Exploiting host immunity: the Salmonella paradigm.

Judith Behnsen, Araceli Perez-Lopez, Sean-Paul Nuccio, Manuela Raffatellu

Open access · greenAbstract readReview
In one paragraph

Review in Trends in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
20.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 137 citations in OpenAlex.

  1. Review
  2. Vitamin D3 contribution to systemic and local control ofFrontiers in molecular biosciences · 2026
    Article
  3. A systems pharmacology-basedFrontiers in veterinary science · 2026
    Article
  4. Review
  5. Article
  6. Comparative Patho-Genomics ofPathogens (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Emerging Strategies against Non-TyphoidalCurrent issues in molecular biology · 2024
    Review
  11. Article
  12. Effects of a novelHeliyon · 2024
    Article
  13. Article
  14. Frontiers in microbiology · 2024
    Article
  15. Review
  16. How Bacterial Pathogens Coordinate Appetite with Virulence.Microbiology and molecular biology reviews : MMBR · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Judith BehnsenDepartment of Microbiology and Molecular Genetics, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA; Institute for Immunology, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Araceli Perez-LopezDepartment of Microbiology and Molecular Genetics, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA; Institute for Immunology, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Sean-Paul NuccioDepartment of Microbiology and Molecular Genetics, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA.
Manuela RaffatelluDepartment of Microbiology and Molecular Genetics, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA; Institute for Immunology, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA. Electronic address: manuelar@uci.edu.
University of California, Irvine · US

Funding

Mucosal barrier function during Salmonella infectionR01AI083663 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI RAFFATELLU, MANUELA · 2010 to 2014
$1.9M
The role of the circadian clock during Salmonella infectionR21AI105374 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI RAFFATELLU, MANUELA, SASSONE-CORSI, PAOLO · 2014 to 2015
$424k
Targeting iron acquisition in Salmonella with siderophore-based immunizationR21AI101784 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2014 to 2015
$418k
NIAID NIH HHS AI083663NIAID NIH HHS AI101784NIAID NIH HHS AI105374NIAID NIH HHS R01 AI083663NIAID NIH HHS R21 AI101784NIAID NIH HHS R21 AI105374
6 · The paper itself

Abstract

Pathogens have evolved clever strategies to evade and in some cases exploit the attacks of an activated immune system. Salmonella enterica is one such pathogen, exploiting multiple aspects of host defense to promote its replication in the host. Here we review recent findings on the mechanisms by which Salmonella establishes systemic and chronic infection, including strategies involving manipulation of innate immune signaling and inflammatory forms of cell death, as well as immune evasion by establishing residency in M2 macrophages. We also examine recent evidence showing that the oxidative environment and the high levels of antimicrobial proteins produced in response to localized Salmonella gastrointestinal infection enable the pathogen to successfully outcompete the resident gut microbiota.

Indexed as

ImmunityAnimalsHost-Pathogen InteractionsHumansIntestinal MucosaIntestinesOxidative StressReactive Nitrogen SpeciesReactive Oxygen SpeciesSalmonellaSalmonella InfectionsToll-Like ReceptorsReactive Nitrogen SpeciesReactive Oxygen SpeciesToll-Like Receptorsimmune evasionimmunityinflammationmucosal immunitySalmonella

Identifiers

PMID25582038
PMCPMC4323876
OpenAlexW2046892194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.