ArticleAnesthesiology2015
Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat.
Article in Anesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Combatting pain after orthopedic/trauma surgery- perioperative oral extended-release tapentadol vs. extended-release oxycodone/naloxone.BMC anesthesiology · 2017Trial
- The Impact of Sex on the Dysfunction of Endogenous Pain Control after Traumatic Brain Injury.Journal of neurotrauma · 2026Article
- Designer Receptor Exclusively Activated by Designer Drug (DREADD)-Mediated Activation of the Periaqueductal Gray Restores Nociceptive Descending Inhibition After Traumatic Brain Injury in Rats.Journal of neurotrauma · 2024Article
- Effect of Voluntary Exercise on Endogenous Pain Control Systems and Post-traumatic Headache in Mice.The journal of pain · 2023Article
- Monoamine control of descending pain modulation after mild traumatic brain injury.Scientific reports · 2022Article
- Activation of the Locus Coeruleus Mediated by Designer Receptor Exclusively Activated by Designer Drug Restores Descending Nociceptive Inhibition after Traumatic Brain Injury in Rats.Journal of neurotrauma · 2022Article
- The efficacy of duloxetine depends on spinal cholinergic plasticity in neuropathic pain model rats.IBRO neuroscience reports · 2022Article
- Spinal microglial β-endorphin signaling mediates IL-10 and exenatide-induced inhibition of synaptic plasticity in neuropathic pain.CNS neuroscience & therapeutics · 2021Article
- Loss of diffuse noxious inhibitory control after traumatic brain injury in rats: A chronic issue.Experimental neurology · 2020Article
- A study of cortical and brainstem mechanisms of diffuse noxious inhibitory controls in anaesthetised normal and neuropathic rats.The European journal of neuroscience · 2020Article
- Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life.Frontiers in pediatrics · 2020Review
- Descending Control Mechanisms and Chronic Pain.Current rheumatology reports · 2019Review
- Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System.International journal of molecular sciences · 2019Review
- Nociceptive and Cognitive Changes in a Murine Model of Polytrauma.The journal of pain · 2018Article
- Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury.Anesthesiology · 2018Article
- Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat.Neuroscience · 2018Article
- Article
- Analgesic Mechanisms of Antidepressants for Neuropathic Pain.International journal of molecular sciences · 2017Review
- The plasticity of descending controls in pain: translational probing.The Journal of physiology · 2017Review
- Efficient conditioned pain modulation despite pain persistence in painful diabetic neuropathy.Pain reports · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and the strength of CPM preoperatively predicts the likelihood of chronic postsurgical pain. The relation between CPM and recovery from surgery has not been examined in preclinical models.
methodsCPM was assessed in individual rats and correlated with each animal's time course of recovery of hypersensitivity after partial spinal nerve ligation. The role of descending noradrenergic pathways in the spinal cord to mechanisms of CPM and recovery was tested using idazoxan to block noradrenergic receptors or antidopamine β-hydroxylase-conjugated saporin to ablate these pathways. Behavioral hypersensitivity, static weight bearing, and spinal glial activation were measured after partial spinal nerve ligation.
resultsThe strength of CPM varied over two-fold between individuals and was directly correlated with the slope of recovery from hypersensitivity after surgery (P < 0.0001; r = 0.660). CPM induced the release of norepinephrine in the spinal cord and was partially blocked by intrathecal idazoxan or dopamine β-hydroxylase-saporin. Dopamine β-hydroxylase-saporin also slowed recovery and enhanced spinal glial activation after partial spinal nerve ligation surgery. Ongoing activation of these pathways was critical to sustained recovery because intrathecal dopamine β-hydroxylase-saporin given 7 weeks after recovery reinstituted hypersensitivity, while having no effect in animals without previous surgery.
conclusionCollectively, these studies provide a clear back-translation from clinical observations of CPM and chronic postsurgical pain and suggest that the ability to engage ongoing descending endogenous noradrenergic signaling may be critical in determining time course of recovery from hypersensitivity after surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.