ArticleAngewandte Chemie (International ed. in English)2015
Ligand-controlled regiodivergent palladium-catalyzed decarboxylative allylation reaction to access α,α-difluoroketones.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Investigation of olefins as a cocatalyst for halonium catalysis.Chemical communications (Cambridge, England) · 2026Article
- Formation of Vicinal Secondary and All-Carbon Quaternary Stereocenters in Enantioenriched Diazenes via Branched-Selective Pd-Catalyzed Allylic Alkylation.Tetrahedron letters · 2025Article
- Catalytic Asymmetric Difluoroalkylation Using In Situ Generated Difluoroenol Species as the Privileged Synthon.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Cu(II)-Catalyzed Unsymmetrical Dioxidation ofThe Journal of organic chemistry · 2022Article
- Highly regioselective and diastereodivergent aminomethylative annulation of dienyl alcohols enabled by a hydrogen-bonding assisting effect.Chemical science · 2022Article
- Ligand-controlled regioselective and chemodivergent defluorinative functionalization ofChemical science · 2021Article
- Decarbonylative Fluoroalkylation at Palladium(II): From Fundamental Organometallic Studies to Catalysis.Journal of the American Chemical Society · 2021Article
- Synthesis of Enantioenriched 3,4-Disubstituted Chromans through Lewis Base Catalyzed Carbosulfenylation.The Journal of organic chemistry · 2021Article
- The Allylic Alkylation of Ketone Enolates.ChemistryOpen · 2020Review
- Nickel-Catalyzed Decarbonylative Synthesis of Fluoroalkyl Thioethers.ACS catalysis · 2020Article
- Decarboxylative aldol reaction of α,α-difluoro-β-ketocarboxylate salt: a facile method for generation of difluoroenolate.RSC advances · 2018Article
- Catalytic Enantioselective and Diastereoselective Allylic Alkylation with Fluoroenolates: Efficient Access to C3-Fluorinated and All-Carbon Quaternary Oxindoles.Angewandte Chemie (International ed. in English) · 2017Article
- Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates.Angewandte Chemie (International ed. in English) · 2016Article
- Dichotomous mechanistic behavior in Narasaka-Heck cyclizations: electron rich Pd-catalysts generate iminyl radicals.Chemical science · 2016Article
- Copper-Catalyzed Cyclopropanol Ring Opening Csp(3)-Csp(3) Cross-Couplings with (Fluoro)Alkyl Halides.Organic letters · 2015Article
- Ligand-Controlled Regioselective Copper-Catalyzed Trifluoromethylation To Generate (Trifluoromethyl)allenes.Organic letters · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
α,α-Difluoroketones possess unique physicochemical properties that are useful for developing therapeutics and probes for chemical biology. To access the α-allyl-α,α-difluoroketone substructure, complementary palladium-catalyzed decarboxylative allylation reactions were developed to provide linear and branched α-allyl-α,α-difluoroketones. For these orthogonal processes, the fluorination pattern of the substrate enabled the ligands to dictate the regioselectivity of the transformations.
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