Evidence map›Paper›PMID 25581708›Full record

ArticleHelicobacter2015

Time Trends in Helicobacter pylori Infection and Atrophic Gastritis Over 40 Years in Japan.

Tomoari Kamada, Ken Haruma, Masanori Ito, Kazuhiko Inoue, Noriaki Manabe, Hiroshi Matsumoto, Hiroaki Kusunoki, Jiro Hata, Masaharu Yoshihara, Koji Sumii and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Helicobacter, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Upper Gastrointestinal Endoscopy in Elderly Patients: An Individualized Decision-Making Approach for Screening and Surveillance.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Review
  4. Helicobacter pylori Management in Older Adults: Current Perspectives From Japan.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Rising Trends of Endoscopic Barrett's Esophagus and Gastric Fundic Gland Polyps in Young Japanese Adults.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Tomoari KamadaDivision of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.
Ken HarumaDivision of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.
Masanori ItoDepartment of Gastroenterology and Metabolism, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
Kazuhiko InoueDepartment of General Medicine, Kawasaki Medical School, Kurashiki, Japan.
Noriaki ManabeDivision of Endoscopy and Ultrasound, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan.
Hiroshi MatsumotoDivision of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.
Hiroaki KusunokiDepartment of General Medicine, Kawasaki Medical School, Kurashiki, Japan.
Jiro HataDivision of Endoscopy and Ultrasound, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan.
Masaharu YoshiharaHealth Service Center, Hiroshima University, Higashihiroshima, Japan.
Koji SumiiDepartment of Internal Medicine, Saiseikai Hiroshima Hospital, Hiroshima, Japan.
Takashi AkiyamaDepartment of Pathology, Kawasaki Medical School, Kurashiki, Japan.
Shinji TanakaDepartment of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
Akiko ShiotaniDivision of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.
David Y GrahamDepartment of Medicine, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA.
Kawasaki Medical School · JPHiroshima University · JPHiroshima University Hospital · JPMichael E. DeBakey VA Medical Center · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORIR01DK062813 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI YAMAOKA, YOSHIO · 2004 to 2013
$3.0M
NIDDK NIH HHS DK56338NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK062813
6 · The paper itself

Abstract

backgroundHelicobacter pylori infection produces progressive mucosal damage that may eventually result in gastric cancer. We studied the changes that occurred in the presence and severity of atrophic gastritis and the prevalence of H. pylori infection that occurred coincident with improvements in economic and hygienic conditions in Japan since World War II. MATERIALS AND

methodsThe prevalence of H. pylori infection and histologic grades of gastric damage were retrospectively evaluated using gastric biopsy specimens obtained over a 40-year period. Gastric atrophy and intestinal metaplasia were scored using the updated Sydney classification system.

resultsThe prevalence of H. pylori and severity of atrophy were examined in 1381 patients including 289 patients examined in the 1970s (158 men; mean age, 44.9 years), 787 in the 1990s (430 men; 44.2 years), and 305 in the 2010s (163 men; 53.2 years). Overall, the prevalence of H. pylori infection decreased significantly from 74.7% (1970s) to 53% (1990s) and 35.1% (2010s) (p < .01). The prevalence of atrophy in the antrum and corpus was significantly lower in the 2010s (33, 19%, respectively) compared to those evaluated in either the 1970s (98, 82%) (p < .001) or 1990s (80, 67%) (p < .001). The severity of atrophy and intestinal metaplasia also declined remarkably among those with H. pylori infection.

conclusionsThere has been a progressive and rapid decline in the prevalence of H. pylori infection as well a fall in the rate of progression of gastric atrophy among H. pylori-infected Japanese coincident with the westernization and improvements in economic and hygienic conditions in Japan since World War II.

Indexed as

AdolescentAdultAgedFemaleGastric MucosaGastritis, AtrophicHelicobacter InfectionsHelicobacter pyloriHumansJapanMaleMetaplasiaMiddle AgedPrevalenceRetrospective StudiesStomachGastric atrophygastric cancerHelicobacter pyloriintestinal metaplasiasalt intakesmoking

Identifiers

PMID25581708
PMCPMC6905084
OpenAlexW2020601232

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.