ArticleEnvironmental microbiology reports2015
Structural conservation of chemotaxis machinery across Archaea and Bacteria.
Article in Environmental microbiology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Distinct roles of PilI and ChpC inApplied and environmental microbiology · 2026Article
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- Composition and in situ structure of theScience advances · 2024Article
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- Mechanisms of E. coli chemotaxis signaling pathways visualized using cryoET and computational approaches.Biochemical Society transactions · 2022Review
- Comparative Genomic Insights into Chemoreceptor Diversity and Habitat Adaptation of Archaea.Applied and environmental microbiology · 2022Article
- Structural insights into the mechanism of archaellar rotational switching.Nature communications · 2022Article
- Hexameric rings of the scaffolding protein CheW enhance response sensitivity and cooperativity inScience signaling · 2022Article
- Towards Elucidating the Rotary Mechanism of the Archaellum Machinery.Frontiers in microbiology · 2022Review
- Diversity of bacterial chemosensory systems.Current opinion in microbiology · 2021Review
- Molecular model of a sensor of two-component signaling system.Scientific reports · 2021Article
- Alternative Architecture of theBiomolecules · 2021Article
- ThemSystems · 2021Article
- How Did the Archaellum Get Its Rotation?Frontiers in microbiology · 2021Review
- A comprehensive history of motility and Archaellation in Archaea.FEMS microbes · 2021Article
- Motile ghosts of the halophilic archaeon,Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The switch complex ArlCDE connects the chemotaxis system and the archaellum.Molecular microbiology · 2020Article
- The chemosensory systems of Vibrio cholerae.Molecular microbiology · 2020Review
- Repurposing a chemosensory macromolecular machine.Nature communications · 2020Article
- Complete structure of the chemosensory array core signalling unit in an E. coli minicell strain.Nature communications · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Chemotaxis allows cells to sense and respond to their environment. In Bacteria, stimuli are detected by arrays of chemoreceptors that relay the signal to a two-component regulatory system. These arrays take the form of highly stereotyped super-lattices comprising hexagonally packed trimers-of-receptor-dimers networked by rings of histidine kinase and coupling proteins. This structure is conserved across chemotactic Bacteria, and between membrane-bound and cytoplasmic arrays, and gives rise to the highly cooperative, dynamic nature of the signalling system. The chemotaxis system, absent in eukaryotes, is also found in Archaea, where its structural details remain uncharacterized. Here we provide evidence that the chemotaxis machinery was not present in the last archaeal common ancestor, but rather was introduced in one of the waves of lateral gene transfer that occurred after the branching of Eukaryota but before the diversification of Euryarchaeota. Unlike in Bacteria, the chemotaxis system then evolved largely vertically in Archaea, with very few subsequent successful lateral gene transfer events. By electron cryotomography, we find that the structure of both membrane-bound and cytoplasmic chemoreceptor arrays is conserved between Bacteria and Archaea, suggesting the fundamental importance of this signalling architecture across diverse prokaryotic lifestyles.
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