Evidence map›Paper›PMID 25581431›Full record

SynthesisNature genetics2015

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

Karoline B Kuchenbaecker, Susan J Ramus, Jonathan Tyrer, Andrew Lee, Howard C Shen, Jonathan Beesley, Kate Lawrenson, Lesley McGuffog, Sue Healey, Janet M Lee and 287 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 9 pooled it
50.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 9 syntheses or guidelines pooled it, 259 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. TERT rs10069690 polymorphism and cancers risk: A meta-analysis.Molecular genetics & genomic medicine · 2019
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

297 authors at 20 institutions in 30 countries.

Karoline B KuchenbaeckerCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Susan J RamusDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.ORCID 0000000300057798
Jonathan TyrerDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Andrew LeeCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Howard C ShenDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Jonathan BeesleyCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Kate LawrensonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Lesley McGuffogCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Sue HealeyCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Janet M LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Tassja J SpindlerDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Yvonne G LinDepartment of Obstetrics and Gynecology, University of Southern California, Los Angeles, California, USA.
Tanja Pejovic1] Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA. [2] Knight Cancer Institute, Portland, Oregon, USA.
Yukie Bean1] Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA. [2] Knight Cancer Institute, Portland, Oregon, USA.
Qiyuan LiDepartment of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Simon Coetzee1] Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. [2] Center for Cell-Based Therapy, Monte Alegre, Ribeirão Preto, Brazil. [3] Center for Integrative Systems Biology, Monte Alegre, Ribeirão Preto, Brazil.
Dennis Hazelett1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. [2] Department of Urology, University of Southern California, Los Angeles, California, USA.
Alexander MironDepartment of Genomics and Genome Sciences, Case Western Reserve University Medical School, Cleveland, Ohio, USA.
Melissa SoutheyGenetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
Mary Beth TerryDepartment of Epidemiology, Columbia University, New York, New York, USA.
David E GoldgarDepartment of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Saundra S BuysDepartment of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Ramunas Janavicius1] Department of Molecular and Regenerative Medicine, Hematology, Oncology and Transfusion Medical Center, Vilinius University Hospital Santariskiu Clinics, Vilnius, Lithuania, Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania. [2] State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
Cecilia M DorflingDepartment of Genetics, University of Pretoria, Pretoria, South Africa.
Elizabeth J van RensburgDepartment of Genetics, University of Pretoria, Pretoria, South Africa.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
Yuan Chun DingDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
Thomas V O HansenCenter for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Lars JønsonCenter for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Anne-Marie GerdesDepartment of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Bent EjlertsenDepartment of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Daniel BarrowdaleCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Joe Dennis1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2] Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.ORCID 0000000345911214
Javier Benitez1] Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [2] Human Genotyping Unit (CEGEN), Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [3] Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
Ana Osorio1] Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [2] Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
Maria Jose Garcia1] Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [2] Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
Ian KomenakaMaricopa Medical Center, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California, USA.
Jeffrey N WeitzelClinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California, USA.
Pamela GanschowCook County Health and Hospital System, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California, USA.
Paolo PeterlongoFondazione Istituto FIRC (Italian Foundation for Cancer Research) di Oncologia Molecolare (IFOM), Milan, Italy.
Loris Bernard1] Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy. [2] Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
Alessandra VielDivision of Experimental Oncology, CRO (Centro di Riferimento Oncologico) Aviano National Cancer Institute, Aviano, Italy.ORCID 0000000328040840
Bernardo BonanniDivision of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy.
Bernard PeisselUnit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico (Italian Research Hospital)) Istituto Nazionale Tumori (INT), Milan, Italy.
Siranoush ManoukianUnit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico (Italian Research Hospital)) Istituto Nazionale Tumori (INT), Milan, Italy.
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy.
Laura PapiUnit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.
Laura OttiniDepartment of Molecular Medicine, University La Sapienza, Rome, Italy.
Florentia FostiraMolecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece.
Irene KonstantopoulouMolecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece.
Judy GarberCancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Debra FrostCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Jo PerkinsCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Radka PlatteCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Steve EllisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
EMBRACE
Andrew K GodwinDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
Rita Katharina Schmutzler1] Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne, Germany. [2] Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany. [3] Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. [4] On behalf of the German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC).
Alfons MeindlDepartment of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Christian SutterInstitute of Human Genetics, University Heidelberg, Heidelberg, Germany.
Olga M Sinilnikova1] INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France. [2] Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon-Centre Léon Bérard, Lyon, France.
GEMO Study Collaborators
Francesca DamiolaINSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Sylvie MazoyerINSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Dominique Stoppa-Lyonnet1] Institut Curie, Department of Tumour Biology, Paris, France. [2] Institut Curie, INSERM U830, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Kathleen ClaesCenter for Medical Genetics, Ghent University, Ghent, Belgium.
Kim De LeeneerCenter for Medical Genetics, Ghent University, Ghent, Belgium.
Judy KirkAustralia New Zealand Gynecologic Oncology Group (ANZGOG) and Familial Cancer Service, Westmead Hosptial, Sydney, New South Wales, Australia.
Gustavo C RodriguezDivision of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, Illinois, USA.
Marion PiedmonteGynecologic Oncology Group, Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, USA.
David M O'MalleyJames Cancer Center, Ohio State University, Columbus, Ohio, USA.
Miguel de la HoyaMolecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain.
Trinidad CaldesMolecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain.
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
J Margriet ColléeDepartment of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID 0000000292729346
Matti A RookusDepartment of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Jan C OosterwijkDepartment of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands.
Breast Cancer Family Registry
Laima TihomirovaLatvian Biomedical Research and Study Centre, Riga, Latvia.
Nadine TungDepartment of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Ute HamannMolecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Claudine IsaccsLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Marc TischkowitzProgram in Cancer Genetics, McGill University, Montreal, Quebec, Canada.
Evgeny N ImyanitovN.N. Petrov Institute of Oncology, St. Petersburg, Russia.
Maria A CaligoSection of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy.
Ian G CampbellVBCRC (Victorian Breast Cancer Research Consortium) Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Frans B L HogervorstFamily Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands.
HEBON
Edith OlahDepartment of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
Orland DiezOncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona, Barcelona, Spain.
Ignacio BlancoGenetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute)-Catalan Institute of Oncology, Barcelona, Spain.
Joan BrunetGenetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona)-Catalan Institute of Oncology, Girona, Spain.
Conxi LazaroMolecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
Miquel Angel PujanaMolecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.ORCID 0000000256500501
Jacek GronwaldDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Grzegorz SukiennickiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Rosa B BarkardottirDepartment of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Marie PlanteGynaecologic Oncology Service, Centre Hospitalier Universitaire de Québec (CHUQ), Quebec City, Quebec, Canada.
Jacques SimardCentre Hospitalier Universitaire de Québec (CHUQ) Research Center, Laval University, Quebec City, Quebec, Canada.
Penny SoucyCentre Hospitalier Universitaire de Québec (CHUQ) Research Center, Laval University, Quebec City, Quebec, Canada.
Marco MontagnaImmunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV)-IRCCS, Padua, Italy.
Silvia TognazzoImmunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV)-IRCCS, Padua, Italy.
Manuel R Teixeira1] Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal. [2] Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.ORCID 0000000248965982
KConFab Investigators
Vernon S PankratzDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Xianshu WangDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Noralane LindorDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Csilla I SzaboNational Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Noah KauffDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Joseph VijaiDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.ORCID 000000027933151X
Carol A AghajanianDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Georg PfeilerDepartment of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Andreas BergerDepartment of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Christian F SingerDepartment of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Muy-Kheng TeaDepartment of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Catherine M PhelanDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Mark H GreeneClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA.ORCID 0000000318529239
Phuong L MaiClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA.
Gad RennertDepartment of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel.
Anna Marie Mulligan1] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. [2] Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.
Sandrine TchatchouLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Irene L Andrulis1] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000000242266435
Gord GlendonLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Amanda Ewart TolandDepartment of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, USA.ORCID 0000000202711792
Uffe Birk JensenDepartment of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
Torben A KruseDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Anders BojesenDepartment of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
Jamal ZidanInstitute of Oncology, Rivka Ziv Medical Center, Zefat, Israel.
Eitan FriedmanSusanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Aviv, Israel.
Yael LaitmanSusanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Aviv, Israel.
Maria SollerDepartment of Clinical Genetics, Lund University Hospital, Lund, Sweden.
Annelie LiljegrenDepartment of Oncology, Karolinska University Hospital, Stockholm, Sweden.
Brita ArverDepartment of Oncology, Karolinska University Hospital, Stockholm, Sweden.
Zakaria EinbeigiDepartment of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Marie Stenmark-AskmalmDivision of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA.
Robert L NussbaumDepartment of Medicine and Genetics, University of California, San Francisco, San Francisco, California, USA.
Timothy R RebbeckAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Katherine L NathansonAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Susan M DomchekAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Karen H LuDepartment of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Beth Y KarlanWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Christine WalshWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Jenny LesterWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Australian Cancer Study (Ovarian Cancer Investigators)
Australian Ovarian Cancer Study Group
Alexander HeinDepartment of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000000326013398
Arif B EkiciInstitute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000000160997066
Matthias W BeckmannDepartment of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany.
Peter A Fasching1] Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany. [2] Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Diether Lambrechts1] Vesalius Research Center, VIB, Leuven, Belgium. [2] Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.
Els Van NieuwenhuysenDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium.
Ignace VergoteDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium.
Sandrina LambrechtsDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium.
Ed DicksDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Jennifer A DohertyDepartment of Community and Family Medicine, Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Kristine G WicklundProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Mary Anne Rossing1] Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington, USA.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Shan Wang-GohrkeDepartment of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
Ursula EilberDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kirsten B MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Kunle OdunsiDepartment of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Lara SuchestonDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Shashi LeleDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Marc T Goodman1] Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. [2] Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Pamela J Thompson1] Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. [2] Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Yurii B ShvetsovCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Ingo B RunnebaumDepartment of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany.
Matthias DürstDepartment of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany.
Peter HillemannsClinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Natalia AntonenkovaByelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus.
Natalia BogdanovaGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Arto LeminenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Liisa M PelttariDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Ralf Butzow1] Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. [2] Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland.
Francesmary Modugno1] Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. [2] Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. [3] Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. [4] Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
Joseph L KelleyDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Robert P Edwards1] Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. [2] Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Roberta B NessUniversity of Texas School of Public Health, Houston, Texas, USA.
Andreas du Bois1] Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany. [2] Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.
Florian Heitz1] Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany. [2] Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.
Ira SchwaabInstitut für Humangenetik Wiesbaden, Wiesbaden, Germany.
Philipp Harter1] Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany. [2] Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.
Keitaro MatsuoDepartment of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan.
Satoyo HosonoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Sandra OrsulicWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Allan JensenDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Susanne Kruger Kjaer1] Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. [2] Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Estrid Hogdall1] Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. [2] Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Hanis Nazihah HasmadCancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia.
Mat Adenan Noor AzmiDepartment of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Soo-Hwang Teo1] Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia. [2] University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Yin-Ling Woo1] Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia. [2] University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Brooke L FridleyBiostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000000177397956
Ellen L GoodeDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000000281593025
Robert A VierkantDepartment of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
Fiona BruinsmaCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Dong LiangCollege of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA.
Michelle A T HildebrandtDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Xifeng WuDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Douglas A LevineGynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.ORCID 0000000310388232
Maria BisognaGynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.
Edwin S IversenDepartment of Statistical Science, Duke University, Durham, North Carolina, USA.
Joellen M Schildkraut1] Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina, USA. [2] Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Patrick Concannon1] Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA. [2] Genetics Institute, University of Florida, Gainesville, Florida, USA.
Rachel Palmieri WeberDepartment of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Daniel W Cramer1] Harvard School of Public Health, Boston, Massachusetts, USA. [2] Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Kathryn L Terry1] Harvard School of Public Health, Boston, Massachusetts, USA. [2] Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Elizabeth M Poole1] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Shelley S Tworoger1] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.ORCID 0000000269867046
Elisa V BanderaCancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Irene OrlowDepartment of Epidemiology and Biostatistics, Epidemiology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Epidemiology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Camilla Krakstad1] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway. [2] Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Helga B Salvesen1] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway. [2] Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Ingvild L Tangen1] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway. [2] Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Line Bjorge1] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway. [2] Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Anne M van AltenaDepartment of Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Katja K H Aben1] Comprehensive Cancer Center The Netherlands, Utrecht, the Netherlands. [2] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands.
Lambertus A Kiemeney1] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands. [2] Department of Urology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Leon F A G MassugerDepartment of Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Melissa Kellar1] Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA. [2] Knight Cancer Institute, Portland, Oregon, USA.
Angela Brooks-Wilson1] Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada. [2] Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Linda E KelemenDepartment of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Linda S CookDivision of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
Nhu D LeCancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Clinic of Opthalmology, Pomeranian Medical University, Szczecin, Poland.
Hannah YangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Louise A BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Claus HogdallDepartment of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Lene LundvallDepartment of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Lotte NedergaardDepartment of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Helen BakerDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Honglin SongDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Diana EcclesWessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK.
Ian McNeishInstitute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK.
James PaulCancer Research UK Clinical Trials Unit, Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK.
Karen CartyCancer Research UK Clinical Trials Unit, Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK.
Nadeem SiddiquiDepartment of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK.
Rosalind GlasspoolCancer Research UK Clinical Trials Unit, Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK.
Alice S WhittemoreDepartment of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
Joseph H RothsteinDepartment of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
Valerie McGuireDepartment of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
Weiva SiehDepartment of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Wei ZhengVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Xiao-Ou ShuVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yu-Tang GaoShanghai Cancer Institute, Shanghai, China.
Barry Rosen1] Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. [2] Department of Gynecologic-Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
John R McLaughlinProsserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Steven A NarodWomen's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
Alvaro N MonteiroDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.ORCID 0000000284484801
Ann ChenDepartment of Biostatistics, Moffitt Cancer Center, Tampa, Florida, USA.
Hui-Yi LinDepartment of Biostatistics, Moffitt Cancer Center, Tampa, Florida, USA.
Jenny Permuth-WeyDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Ya-Yu TsaiDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Zhihua ChenDepartment of Biostatistics, Moffitt Cancer Center, Tampa, Florida, USA.
Argyrios ZiogasDepartment of Epidemiology, University of California-Irvine, Irvine, California, USA.ORCID 0000000345293727
Hoda Anton-CulverDepartment of Epidemiology, University of California-Irvine, Irvine, California, USA.
Aleksandra Gentry-MaharajWomen's Cancer, University College London Elizabeth Garrett Anderson (EGA) Institute for Women's Health, London, UK.
Usha MenonWomen's Cancer, University College London Elizabeth Garrett Anderson (EGA) Institute for Women's Health, London, UK.
Patricia HarringtonDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Alice W LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Celeste L PearceDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Gerry Coetzee1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. [2] Department of Urology, University of Southern California, Los Angeles, California, USA.
Malcolm C Pike1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. [2] Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Agnieszka Dansonka-MieszkowskaDepartment of Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Agnieszka TimorekDepartment of Obstetrics, Gynecology and Oncology, 2nd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.
Iwona K RzepeckaDepartment of Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Jolanta KupryjanczykDepartment of Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Matt FreedmanDepartment of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Houtan NoushmehrDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Kenneth OffitDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Fergus J Couch1] Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. [2] Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Simon GaytherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Paul P PharoahDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Georgia Chenevix-TrenchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Consortium of Investigators of Modifiers of BRCA1 and BRCA2
University of Cambridge · GBUniversity of Southern California · USMemorial Sloan Kettering Cancer Center · USCedars-Sinai Medical Center · USBrigham and Women's Hospital · USRoswell Park Comprehensive Cancer Center · USUniversity of Copenhagen · DKFriedrich-Alexander-Universität Erlangen-Nürnberg · DEMayo Clinic · USMount Sinai Hospital · CAThe University of Texas MD Anderson Cancer Center · USUniversité Claude Bernard Lyon 1 · FRUniversity of Toronto · CAGerman Cancer Research Center · DEOregon Health & Science University · USUniversity of Helsinki · FICity Of Hope National Medical Center · USCopenhagen University Hospital · DKHelios Dr. Horst Schmidt Kliniken Wiesbaden · DEInstitut d'Investigació Biomédica de Bellvitge · ES

Funding

NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Statistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI James J. Dignam, GREG YOTHERS · 2014 to 2026
$146.4M
NRG Oncology NCORP Research Base-BIQSFPUG1CA189867 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Deborah Watkins Bruner, Lisa A. Kachnic · 2014 to 2026
$140.5M
GYNECOLOGIC ONCOLOGY GROUP HEADQUARTERSU10CA027469 · NCI · GYNECOLOGIC ONCOLOGY GROUP · PI DISAIA, PHILIP J. · 1985 to 2013
$132.6M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
GYNECOLOGIC ONCOLOGY GROUP STATISTICAL OFFICEU10CA037517 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI BLESSING, JOHN A · 1985 to 2013
$67.4M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI Fergus Joseph Couch · 2005 to 2026
$49.9M
NRG Oncology Biospecimen BankU24CA196067 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Tanner J. Freeman, Nilsa Del Carmen Ramirez Milan · 2015 to 2026
$42.6M
Cancer Research UK 10124Cancer Research UK 11174Cancer Research UK 12677Cancer Research UK 15960Cancer Research UK 16561Cancer Research UK 16563Cancer Research UK 16565Cancer Research UK 17523Cancer Research UK C12292/A11174Cancer Research UK C1287/A10118NCATS NIH HHS UL1 TR000005NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA116201NCI NIH HHS P50 CA136393NCI NIH HHS P50 CA159981NCI NIH HHS R01 CA087538NCI NIH HHS R01 CA126841NCI NIH HHS R01 CA140323NCI NIH HHS R01 CA176785NCI NIH HHS R25 CA174664NCI NIH HHS RC4 CA153828NCI NIH HHS U01 CA116167NCI NIH HHS U10 CA027469NCI NIH HHS U10 CA037517NCI NIH HHS U10 CA180822NCI NIH HHS U10 CA180838NCI NIH HHS U10 CA180850NCI NIH HHS U10 CA180867NCI NIH HHS U10 CA180868NCI NIH HHS U19 CA148112NCI NIH HHS U19-CA148112NCI NIH HHS U24 CA196067NCI NIH HHS UG1 CA189867NCI NIH HHS UG1 CA233180NCI NIH HHS UM1 CA164920NCI NIH HHS UM1 CA182910Wellcome TrustWellcome Trust 076113
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdolescentAdultAllelesBRCA1 ProteinBRCA2 ProteinCarcinoma, Ovarian EpithelialFemaleGenes, ReporterGenome-Wide Association StudyGenotypeHeterozygoteHumansMutationNeoplasms, Glandular and EpithelialBRCA1 ProteinBRCA2 Protein

Identifiers

PMID25581431
PMCPMC4445140
OpenAlexW2095936660

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.