ArticleJournal of child psychology and psychiatry, and allied disciplines2015
White matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- White matter alterations in Attention-Deficit/Hyperactivity Disorder (ADHD): a systematic review of 129 diffusion imaging studies with meta-analysis.Molecular psychiatry · 2023Pooled it
- Predictors of persistence of ADHD into adulthood: a systematic review of the literature and meta-analysis.European child & adolescent psychiatry · 2016Pooled it
- d-Amphetamine Transdermal System in Treatment of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Secondary Endpoint Results andJournal of child and adolescent psychopharmacology · 2023Trial
- Translating Attention-Deficit/Hyperactivity Disorder Rating Scale-5 and Weiss Functional Impairment Rating Scale-Parent Effectiveness Scores into Clinical Global Impressions Clinical Significance Levels in Four Randomized Clinical Trials of SPN-812 (Viloxazine Extended-Release) in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder.Journal of child and adolescent psychopharmacology · 2021Trial
- Article
- Childhood white matter morphology and longitudinal change in symptoms of attention-deficit/hyperactivity disorder.Developmental medicine and child neurology · 2026Article
- Asymmetry of attentive networks contributes to adult Attention-deficit/hyperactivity disorder (ADHD) pathophysiology.European archives of psychiatry and clinical neuroscience · 2025Article
- The Relationship Between Motor Development and ADHD: A Critical Review and Future Directions.Behavioral sciences (Basel, Switzerland) · 2025Review
- Sex differences in physiological correlates of affectively driven decision-making behavior in adult ADHD.BMC psychiatry · 2024Article
- Multimodal Virtual Reality-Based Assessment of Adult ADHD: A Feasibility Study in Healthy Subjects.Assessment · 2023Article
- Altered interaction of physiological activity and behavior affects risky decision-making in ADHD.Frontiers in human neuroscience · 2023Article
- Drinking alcohol to cope with hyperactive ADHD? Self-reports vs. continuous performance test in patients with ADHD and/or alcohol use disorder.Frontiers in psychiatry · 2023Article
- Sex differences in microstructural alterations in the corpus callosum tracts in drug-naïve children with ADHD.Brain imaging and behavior · 2022Article
- Change Blindness in Adolescents With Attention-Deficit/Hyperactivity Disorder: Use of Eye-Tracking.Frontiers in psychiatry · 2022Article
- Associations between attention-deficit hyperactivity disorder (ADHD) symptom remission and white matter microstructure: A longitudinal analysis.JCPP advances · 2021Article
- Structural brain network topology underpinning ADHD and response to methylphenidate treatment.Translational psychiatry · 2021Article
- Adolescent Attention-Deficit/Hyperactivity Disorder: Understanding Teenage Symptom Trajectories.Biological psychiatry · 2021Review
- White Matter Changes With Rehabilitation in Children With Developmental Coordination Disorder: A Randomized Controlled Trial.Frontiers in human neuroscience · 2021Article
- Quantitative tractography reveals changes in the corticospinal tract in drug-naïve children with attention-deficit/hyperactivity disorderJournal of psychiatry & neuroscience : JPN · 2020Article
- Gender differences in adult ADHD: Cognitive function assessed by the test of attentional performance.PloS one · 2020Article
Corrections and comments
- Erratum issuedErratum.2016
Authors and funding
11 authors.
Funding
Abstract
backgroundA developmental improvement of symptoms in attention-deficit/hyperactivity disorder (ADHD) is frequently reported, but the underlying neurobiological substrate has not been identified. The aim of this study was to determine whether white matter microstructure is related to developmental improvement of ADHD symptoms.
methodsA cross-sectional magnetic resonance imaging (MRI) analysis was embedded in a prospective follow-up of an adolescent cohort of ADHD and control subjects (NeuroIMAGE). Mean age at baseline was 11.9 years, mean interval of follow-up was 5.9 years. About 75.3% of the original cohort was retained successfully. Data of 101 participants with ADHD combined type at baseline and 40 healthy controls were analysed. ADHD symptoms were measured with semistructured, investigator-based interviews and Conners' questionnaires, on the basis of DSM-IV criteria. Fractional anisotropy (FA) and mean diffusivity (MD) indices of white matter microstructure were measured using whole brain diffusion tensor imaging at follow-up only. In a dimensional analysis FA and MD were related to change in ADHD symptoms. To link this analysis to DSM-IV diagnoses, a post hoc categorical group analysis was conducted comparing participants with persistent (n = 59) versus remittent (n = 42) ADHD and controls.
resultsOver time, participants with ADHD showed improvement mainly in hyperactive/impulsive symptoms. This improvement was associated with lower FA and higher MD values in the left corticospinal tract at follow-up. Findings of the dimensional and the categorical analysis strongly converged. Changes in inattentive symptoms over time were minimal and not related to white matter microstructure.
conclusionsThe corticospinal tract is important in the control of voluntary movements, suggesting the importance of the motor system in the persistence of hyperactive/impulsive symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.