ArticleRespirology (Carlton, Vic.)2015
Respiratory impedance in healthy unsedated South African infants: effects of maternal smoking.
Article in Respirology (Carlton, Vic.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Pulmonary Function Testing in Healthy Infants in Rural Bangladesh: Feasibility Study.Pediatric pulmonology · 2025Article
- The impact of antenatal and postnatal indoor air pollution or tobacco smoke exposure on lung function at 3 years in an African birth cohort.Respirology (Carlton, Vic.) · 2023Article
- Respiratory Oscillometry in Newborn Infants: Conventional and Intra-Breath Approaches.Frontiers in pediatrics · 2022Article
- Intra-breath measures of respiratory mechanics in healthy African infants detect risk of respiratory illness in early life.The European respiratory journal · 2019Article
- Question 3: Can we diagnose asthma in children under the age of 5 years?Paediatric respiratory reviews · 2019Review
- Early-life exposure to indoor air pollution or tobacco smoke and lower respiratory tract illness and wheezing in African infants: a longitudinal birth cohort study.The Lancet. Planetary health · 2017Article
- The association between environmental tobacco smoke exposure and childhood respiratory disease: a review.Expert review of respiratory medicine · 2017Review
- Article
- Lung Function in African Infants in the Drakenstein Child Health Study. Impact of Lower Respiratory Tract Illness.American journal of respiratory and critical care medicine · 2017Article
- Lung function and exhaled nitric oxide in healthy unsedated African infants.Respirology (Carlton, Vic.) · 2015Article
- Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy.The journal of allergy and clinical immunology. In practiceArticle
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
objectiveNon-invasive techniques for measuring lung mechanics in infants are needed for a better understanding of lung growth and function, and to study the effects of prenatal factors on subsequent lung growth in healthy infants. The forced oscillation technique requires minimal cooperation from the individual but has rarely been used in infants. The study aims to assess the use of the forced oscillation technique to measure the influence of antenatal exposures on respiratory mechanics in unsedated infants enrolled in a birth cohort study in Cape Town, South Africa.
methodsHealthy term infants were studied at 6-10 weeks of age using the forced oscillation technique. Respiratory impedance was measured in the frequency range 8-48 Hz via a face mask during natural sleep. Respiratory system resistance, compliance and inertance were calculated from the impedance spectra.
resultsOf 177 infants tested, successful measurements were obtained in 164 (93%). Median (25-75%) values for resistance, compliance and inertance were 50.2 (39.5-60.6) cmH2 O.s.L(-1), 0.78 (0.61-0.99) mL.cmH2 O(-1) and 0.062 (0.050-0.086) cmH2 O.s(2) .L(-1), respectively. As a group, male infants had 16% higher resistance (P = 0.006) and 18% lower compliance (P = 0.02) than females. Infants whose mothers smoked during pregnancy had a 19% lower compliance than infants not exposed to tobacco smoke during pregnancy (P = 0.005). Neither maternal HIV infection nor ethnicity had a significant effect on respiratory mechanics.
conclusionsThe forced oscillation technique is sensitive enough to demonstrate the effects of tobacco smoke exposure and sex in respiratory mechanics in healthy infants. This technique will facilitate assessing perinatal influences of lung function in infancy.
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