Evidence map›Paper›PMID 25581207›Full record

Trial reportColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2015

Colorectal adenomas and diabetes: implications for disease prevention.

R J C Steele, A S Anderson, M Macleod, A M Craigie, S Caswell, J Belch, S Treweek, BeWEL team

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

R J C SteeleCentre for Research into Cancer Prevention and Screening, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
A S AndersonCentre for Research into Cancer Prevention and Screening, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
M MacleodCentre for Research into Cancer Prevention and Screening, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0002-7536-8198
A M CraigieCentre for Research into Cancer Prevention and Screening, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
S CaswellCentre for Research into Cancer Prevention and Screening, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
J BelchVascular Diseases Research Unit, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
S TreweekHealth Services Research Unit, University of Aberdeen, Aberdeen, UK.
BeWEL team
University of Dundee · GBUniversity of Aberdeen · GB

Funding

Biotechnology and Biological Sciences Research CouncilCancer Research UKChief Scientist Office HSRU1Department of HealthMedical Research Council G0802030
6 · The paper itself

Abstract

aimThis study assessed the baseline type II diabetes mellitus (T2DM) risk status among overweight patients with screen-detected colorectal adenomas and explored the implications of the findings for preventative practice.

methodParticipants aged between 50 and 74 years (73% of whom were men) were recruited from four Scottish health boards and assessed for diabetes risk. Participants were categorized as at 'high' diabetes risk if glycated haemoglobin (HbA1c) was between 6.0 and 6.4% or fasting plasma glucose (FPG) was between 5.5 and 6.9 mmol/l and as potentially undiagnosed T2DM when HbA1c ≥ 6.5% or FPG ≥ 7 mmol/l. Secondary outcome measures included anthropometric measurements, blood pressure and the plasma lipid profile. The tests were repeated at 12 months and diabetes risk categories were reassessed following intervention procedures.

resultsForty-seven (14.3%) of the 329 participants had a preexisting diagnosis of T2DM. Of the remainder with complete biochemistry results (n = 250), 19 (7.6%) were classified as having potentially undiagnosed T2DM and 125 (50.0%) as being at high risk of developing diabetes. More than a quarter of participants in all categories had raised waist circumference, hypertension and plasma lipids, indicative of raised cardiovascular risk. At 12 months' follow-up, the diabetes risk category diminished in 20% of the intervention group vs 11% in the controls [OR 2.26 (95% CI 1.03-4.96)].

conclusionOur results suggest that a diagnosis of adenoma in overweight patients provides a health service opportunity for diabetes assessment, prevention and management in a high-risk population at a potentially teachable moment.

Indexed as

AdenomaAgedAnthropometryBlood GlucoseBlood PressureCardiovascular DiseasesColorectal NeoplasmsDiabetes Mellitus, Type 2FastingFemaleGlycated HemoglobinHumansLipidsMaleMass ScreeningMiddle AgedBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanLipidsAdenomacardiovasculardiabetesobesityscreening

Identifiers

PMID25581207
PMCPMC4833180
OpenAlexW1974923724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.