ArticleAngewandte Chemie (International ed. in English)2015
Double heteroatom functionalization of arenes using benzyne three-component coupling.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Easy access to polyhalogenated biaryls: regioselective (di)halogenation of hypervalent bromines and chlorines.Chemical science · 2024Article
- Regioselective difunctionalization of pyridinesChemical science · 2021Article
- Sequential cycloaddition and ring expansion reaction of arynes and methylenebenzothiopheneones: synthesis of a benzo-fused eight-membered ringRSC advances · 2019Article
- 1,2-Bis(arylthio)arene synthesis via aryne intermediates.Chemical communications (Cambridge, England) · 2019Article
- Quantification of the Electrophilicity of Benzyne and Related Intermediates.Journal of the American Chemical Society · 2016Article
- Metal Free Bi(hetero)aryl Synthesis: A Benzyne Truce-Smiles Rearrangement.Angewandte Chemie (International ed. in English) · 2016Article
- Boryl (Hetero)aryne Precursors as Versatile Arylation Reagents: Synthesis through C-H Activation and Orthogonal Reactivity.Angewandte Chemie (International ed. in English) · 2015Article
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3 authors.
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Abstract
Arynes participate in three-component coupling reactions with N, S, P, and Se functionalities to yield 1,2-heteroatom-difunctionalized arenes. Using 2-iodophenyl arylsulfonates as benzyne precursors, we could effectively add magnesiated S-, Se-, and N-nucleophilic components to the strained triple bond. In the same pot, addition of electrophilic N, S, or P reagents and a copper(I) catalyst trapped the intermediate aryl Grignard to produce a variety of 1,2-difunctionalized arenes.
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