Trial reportArthritis care & research2015
Characterizing Pain Flares From the Perspective of Individuals With Symptomatic Knee Osteoarthritis.
Trial report in Arthritis care & research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Adolescents' experiences of fluctuating pain in musculoskeletal disorders: a qualitative systematic review and thematic synthesis.BMC musculoskeletal disorders · 2020Pooled it
- Pooled it
- Pooled it
- The Relation of Within-Day Physical Activity Patterns With All-Cause Mortality in Adults With Knee Osteoarthritis: Findings From the Osteoarthritis Initiative.Arthritis care & research · 2026Observational
- Applying the health belief model to understand the usage and experience of self-management techniques in knee osteoarthritis: A mixed-methods observational study.International journal of nursing studies advances · 2026Article
- Exploring the bidirectional temporal association between daily knee pain and physical activity in people with knee osteoarthritis: An exploratory smartwatch study.Osteoarthritis and cartilage open · 2026Article
- Associations Between Daily Symptoms and Pain Flares in Rheumatoid Arthritis: Case-Crossover mHealth Study.JMIR mHealth and uHealth · 2025Article
- Temporal Associations of Physical Activity With Subsequent Knee Pain in Individuals With Knee Osteoarthritis: An Ecological Momentary Assessment Study.European journal of pain (London, England) · 2025Article
- The Patient Experience of Living With Knee Osteoarthritis Pain: Development of a Conceptual Model.Musculoskeletal care · 2025Review
- Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives.Pain and therapy · 2024Review
- Article
- Assessment of Pain in Osteoarthritis of the Knee.Journal of personalized medicine · 2023Review
- How do people with knee osteoarthritis perceive and manage flares? A qualitative study.BJGP open · 2022Article
- Osteoarthritis Flares.Clinics in geriatric medicine · 2022Review
- Pain descriptors and determinants of pain sensitivity in knee osteoarthritis: a community-based cross-sectional study.Rheumatology advances in practice · 2022Article
- A novel mice model of acute flares in osteoarthritis elicited by intra-articular injection of cultured mast cells.Journal of experimental orthopaedics · 2021Article
- Perineural local anesthetic treatments for osteoarthritic pain.Regenerative engineering and translational medicine · 2021Article
- Co-existing patterns of MRI lesions were differentially associated with knee pain at rest and on joint loading: a within-person knee-matched case-controls study.BMC musculoskeletal disorders · 2020Article
- The Association Between Daily Physical Activity and Pain Among Patients with Knee Osteoarthritis: The Moderating Role of Pain Catastrophizing.Pain medicine (Malden, Mass.) · 2019Article
- Acute Flares of Knee Osteoarthritis (the ACT-FLARE Study): Protocol for a Web-Based Case-Crossover Study in Community-Dwelling Adults.JMIR research protocols · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveAlthough pain in knee osteoarthritis (OA) commonly affects activity engagement, the daily pain experience has not been fully characterized. Specifically, the nature and impact of pain flares is not well understood. This study characterized pain flares as defined by participants with knee OA. Pain flare occurrence and experience were measured over 7 days.
methodsThis was a multiple methods study; qualitative methods were dominant. Data were collected during the baseline portion of a randomized controlled trial. Participants met criteria for knee OA and had moderate to severe pain. They completed questionnaires and a 7-day home monitoring period that captured momentary symptom reports simultaneously with physical activity via accelerometry (n = 45). Participants also provided individual definitions of pain flare that were used throughout the home monitoring period to indicate whether a pain flare occurred.
resultsPain flares were described most often by quality (often sharp), followed by timing (seconds, minutes) and by antecedents and consequences. When asked if their definition of a flare agreed with a supplied definition, 49% of the sample reported only "somewhat," "a little," or "not at all." Using individual definitions, 78% experienced at least 1 daily pain flare over the home monitoring period; 24% had a flare on more than 50% of the monitored days.
conclusionPain flares were common, fleeting, and often experienced in the context of activity engagement. Participants' views on what constitutes a pain flare differ from commonly accepted definitions. Pain flares are an understudied aspect of the knee OA pain experience and require further characterization.
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