ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2015
Decreased FEV1 % in asthmatic adults in Scottish homes with high Environmental Relative Moldiness Index values.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- HEPA filtration intervention in classrooms may improve some students' asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome.Clinics in chest medicine · 2020Review
- Indoor mold odor in the workplace increases the risk of Asthma-COPD Overlap Syndrome: a population-based incident case-control study.Clinical and translational allergy · 2020Article
- Comparison of Mold Populations in Water-Damaged Homes in Australia and the United States.Fungal genomics & biology · 2017Article
- Allergen-encoded signals that control allergic responses.Current opinion in allergy and clinical immunology · 2016Review
- Application of the Environmental Relative Moldiness Index in Finland.Applied and environmental microbiology · 2016Article
- Indoor Fungal Exposure and Allergic Respiratory Disease.Current allergy and asthma reports · 2015Review
- Decreased FEV1 % in asthmatic adults in Scottish homes with high Environmental Relative Moldiness Index values.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
- Dampness, indoor mould, fungal DNA and respiratory health - molecular methods in indoor epidemiology.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundExposures to indoor biological contaminants have been implicated in asthma's aetiology but their effect on lung function is not well quantified.
objectiveThe aim of this cross-sectional study of non-smoking, asthmatic adults in Scotland was to determine the correlation between the results from a standard spirometry test, forced expiratory volume in one-second percent (FEV1 %), and quantitative estimates of some biological exposures.
methodsA population (n = 55) of non-smoking, adult asthmatics in Scotland was included in this study and each completed a questionnaire that allowed the determination of the Asthma Control Questionnaire scores (ACQ) and St. George's Respiratory Questionnaire scores (SGRQ), as well as corticosteroid use. Spirometry testing was completed and the pre-bronchodilator FEV1 % value calculated. At about the same time, floor dust samples were collected in the living room and in the bedroom. These dust samples were analysed for mould contamination, as described by the Environmental Relative Moldiness Index (ERMI) values and by (1, 3)-β-D-glucan concentrations, for endotoxin, and for dust mite, cat, and dog allergen concentrations. The asthmatics' FEV1 % values were tested for correlation (Pearson) to questionnaire-based estimates of health. Also, each biological exposure was tested for correlation (Pearson) to the FEV1 % values.
resultsFEV1 % results were correlated with ACQ scores (ρ -0.586, P < 0.001), SGRQ scores (ρ -0.313, P = 0.020), and weakly with corticosteroid use (ρ -0.221, P = 0.105). The ERMI values in the homes (average 5.3) were significantly correlated with FEV1 % values (ρ -0.378, P = 0.004). There was no correlation between FEV1 % and concentrations of endotoxin, (1, 3)-β-D-glucan, or any of the allergens. CONCLUSION AND CLINICAL RELEVANCE: Although these results do not prove that mould exposures caused the deficit in lung function observed in this study, it might be advisable for asthmatics to avoid high ERMI environments.
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