ReviewMalaria research and treatment2014
Exploiting unique structural and functional properties of malarial glycolytic enzymes for antimalarial drug development.
Review in Malaria research and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Chemoproteomics-based profiling elucidates the antimalarial effects of amodiaquine through disruption of glycolysis process in Plasmodium falciparum.Cell communication and signaling : CCS · 2026Article
- Integrative proteomic profiling of malaria-derived microparticles: A mass spectrometry-based study.MalariaWorld journal · 2026Article
- Inhibition Mechanism and Target Reassessment of Potent Piperaquine Analogs: Evidence forACS omega · 2025Article
- Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody.eLife · 2025Article
- Targeting Malaria's Achilles' Heels: A Review of Plasmodium Life Cycle Vulnerabilities for Drug Discovery.Current topics in medicinal chemistry · 2025Review
- Dual role of lactate in human health and disease.Frontiers in physiology · 2025Review
- Article
- Structural Analysis ofInternational journal of molecular sciences · 2023Article
- Malaria therapeutics: are we close enough?Parasites & vectors · 2023Review
- Identification of sulfenylation patterns in trophozoite stage Plasmodium falciparum using a non-dimedone based probe.Molecular and biochemical parasitology · 2021Article
- Article
- Antimalarial Properties of Isoquinoline Derivative fromBioMed research international · 2020Article
- Covalent Inhibitors ofACS medicinal chemistry letters · 2019Article
- A large scale Plasmodium vivax- Saimiri boliviensis trophozoite-schizont transition proteome.PloS one · 2017Article
- Modeling of the Glycolysis Pathway in Plasmodium falciparum using Petri Nets.Bioinformatics and biology insights · 2016Article
- Proteomic analysis of microparticles isolated from malaria positive blood samples.Proteome science · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic enzymes have been known to carry out a variety of functions besides their normal housekeeping roles known as "moonlighting functions." These functionalities arise from structural changes induced by posttranslational modifications and/or binding of interacting proteins. Glycolysis is the sole source of energy generation for malaria parasite Plasmodium falciparum, hence a potential pathway for therapeutic intervention. Crystal structures of several P. falciparum glycolytic enzymes have been solved, revealing that they exhibit unique structural differences from the respective host enzymes, which could be exploited for their selective targeting. In addition, these enzymes carry out many parasite-specific functions, which could be of potential interest to control parasite development and transmission. This review focuses on the moonlighting functions of P. falciparum glycolytic enzymes and unique structural differences and functional features of the parasite enzymes, which could be exploited for therapeutic and transmission blocking interventions against malaria.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.