ReviewOxidative medicine and cellular longevity2014
Free radicals in adolescent varicocele testis.
Review in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Don't wait any longer, conceive in time: a systematic review and meta-analysis based on semen parameters after varicocelectomy.International urology and nephrology · 2024Pooled it
- Risk factors associated with varicocele: a narrative review.Translational andrology and urology · 2025Review
- Mean platelet volume might be an effective indicator of poor semen quality in varicocele patients.International urology and nephrology · 2024Article
- Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats.BMC complementary medicine and therapies · 2022Article
- Sperm and testicular dysfunction during cecal ligation and puncture-induced sepsis in male rats and effects of tannic acid through reducing testicular oxidative stress and inflammation.Iranian journal of basic medical sciences · 2021Article
- Lycopene Attenuates Hypoxia-Induced Testicular Injury by Inhibiting PROK2 Expression and Activating PI3K/AKT/mTOR Pathway in a Varicocele Adult Rat.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Nutraceutical Effects of Lycopene in Experimental Varicocele: An "In Vivo" Model to Study Male Infertility.Nutrients · 2020Article
- Reduced sperm telomere length in individuals with varicocele is associated with reduced genomic integrity.Scientific reports · 2019Article
- Resveratrol decreases apoptosis and NLRP3 complex expressions in experimental varicocele rat model.Iranian journal of basic medical sciences · 2018Article
- Varicocele and male infertility.Nature reviews. Urology · 2017Review
- Is testing of sperm DNA fragmentation (SDF) ready for the basic work-up of male infertility?Translational andrology and urology · 2017Article
- The Dilemma of Adolescent Varicoceles: Do They Really Have to Be Repaired?Current urology reports · 2017Review
- Article
- Detection and Quantification of Free Radicals in Peroxisomal Disorders: A Comparative Study with Oxidative Stress Parameters.Journal of clinical and diagnostic research : JCDR · 2015Article
- The evolution and refinements of varicocele surgery.Asian journal of andrologyReview
- Varicoceles in the pediatric population: Diagnosis, treatment, and outcomes.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaReview
- Mitochondrial Genetic Variation in Iranian Infertile Men with Varicocele.International journal of fertility & sterilityArticle
- Does total testicular volume predict testicular volume difference in adolescent males with varicocele?International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examine the relationship between the structure and function of the testis and the oxidative and nitrosative stress, determined by an excessive production of free radicals and/or decreased availability of antioxidant defenses, which occur in the testis of adolescents affected by varicocele. Moreover, the effects of surgical treatment on oxidative stress were provided. We conducted a PubMed and Medline search between 1980 and 2014 using "adolescent," "varicocele," "free radicals," "oxidative and nitrosative stress," "testis," and "seminiferous tubules" as keywords. Cross-references were checked in each of the studies, and relevant articles were retrieved. We conclude that increased concentration of free radicals, generated by conditions of hypoxia, hyperthermia, and hormonal dysfunction observed in adolescent affected by varicocele, can harm germ cells directly or indirectly by influencing nonspermatogenic cells and basal lamina. With regard to few available data in current literature, further clinical trials on the pre- and postoperative ROS and RNS levels together with morphological studies of the cellular component of the testis are fundamental for complete comprehension of the role played by free radicals in the pathogenesis of adolescent varicocele and could justify its pharmacological treatment with antioxidants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.