Evidence map›Paper›PMID 25580165›Full record

ArticleCellular and molecular bioengineering2011

Bone Physiology, Biomaterial and the Effect of Mechanical/Physical Microenvironment on MSC Osteogenesis: A Tribute to Shu Chien's 80th Birthday.

Xiaoling Liao, Shaoying Lu, Yue Zhuo, Christina Winter, Wenfeng Xu, Bo Li, Yingxiao Wang

Abstract read
In one paragraph

Article in Cellular and molecular bioengineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoling LiaoBiomaterials and Live Cell Imaging Institute, School of Metallurgy and Materials Engineering, Chongqing University of Science and technology, Chongqing, 401331, P.R. China ; Department of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801.
Shaoying LuDepartment of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801.
Yue ZhuoDepartment of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801.
Christina WinterDepartment of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801.
Wenfeng XuBiomaterials and Live Cell Imaging Institute, School of Metallurgy and Materials Engineering, Chongqing University of Science and technology, Chongqing, 401331, P.R. China.
Bo LiBiomaterials and Live Cell Imaging Institute, School of Metallurgy and Materials Engineering, Chongqing University of Science and technology, Chongqing, 401331, P.R. China.
Yingxiao WangDepartment of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801 ; Center for Biophysics and Computational Biology, Department of Integrative and Molecular Physiology, Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, IL 61801.

Funding

Role of Spatiotemporal Epigenetic Dynamics in Regulating Endothelial Gene Expressions under FlowsR01HL121365 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHIEN, SHU, WANG, YINGXIAO · 2014 to 2025
$7.5M
FRET Imaging of Molecular Hierarchy at Subcellular Levels in MechanotransductionR01HL098472 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WANG, YINGXIAO · 2010 to 2014
$1.9M
Mechanical Force and Neural RegenerationR01NS063405 · NINDS · UNIVERSITY OF MIAMI CORAL GABLES · PI CHIBA, AKIRA, JAKOBSSON, ERIC G · 2008 to 2011
$1.2M
The Integration of FLIM and FRET for the Visualization of Flow-induced MolecularK02HL109142 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WANG, YINGXIAO · 2011 to 2015
$549k
The integration of FLIM with FRET biosensors for the sub-cellular visualization oR21CA139272 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WANG, YINGXIAO · 2009 to 2010
$443k
NCI NIH HHS R21 CA139272NHLBI NIH HHS K02 HL109142NHLBI NIH HHS R01 HL098472NHLBI NIH HHS R01 HL121365NINDS NIH HHS R01 NS063405
6 · The paper itself

Abstract

Professor Shu Chien is a world-renowned leader and founder of Bioengineering. In particular, he has made seminal contributions to advancing our systematic and insightful understanding of how cells perceive their physical/mechanical environment and coordinate cellular functions. In this review, as part of a tribute to Prof. Shu Chien's scientific achievement, we summarize the research progress in understanding the physiology of bone cells interacting with different mechanical/physical environments during bone tissue regeneration/repair. We first introduce the cellular composition of the bone tissue and the mechanism of the physiological bone regeneration/repair process. We then describe the properties and development of biomaterials for bone tissue engineering, followed by the highlighting of research progresses on the cellular response to mechanical environmental cues. Finally, several latest advancements in bone tissue regeneration and remaining challenges in the field are discussed for future research directions.

Indexed as

Bone cellsBone repairMechanical EnvironmentscaffoldsTissue engineering

Identifiers

PMID25580165
PMCPMC4288028

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.