ArticleStem cells international2014
Prognostic value of glioma cancer stem cell isolation in survival of primary glioblastoma patients.
Article in Stem cells international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Do relevant markers of cancer stem cells CD133 and Nestin indicate a poor prognosis in glioma patients? A systematic review and meta-analysis.Journal of experimental & clinical cancer research : CR · 2015Pooled it
- Putative glioblastoma origin-like cells in the subventricular zone: isolation and characterization.Experimental & molecular medicine · 2026Article
- Prognostic significance of oligodendrocyte transcription factor 2 expression in glioma patients: A systematic review and meta-analysis.World journal of clinical cases · 2024Article
- PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells.Frontiers in oncology · 2022Article
- Reply to D'Alessandris et al.: Clear evidence of differences between tumor-resident mesenchymal stemlike cells and bone marrow-derived mesenchymal stem cells.Neuro-oncology · 2021Article
- Glioblastoma Cellular Origin and the Firework Pattern of Cancer Genesis from the Subventricular Zone.Journal of Korean Neurosurgical Society · 2020Article
- The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity.Stem cells international · 2019Article
- Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival.Scientific reports · 2018Article
- The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response.Neuro-oncology · 2017Article
- A comprehensive approach in high-grade glioma management: position statement from the Neuro-Oncology Scientific Club (NOSC), Shiraz, Iran.German medical science : GMS e-journal · 2017Review
- Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs.Cancer cell international · 2016Article
- Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma.Stem cells international · 2016Article
- Success of tumorsphere isolation from WHO grade IV gliomas does not correlate with the weight of fresh tumor specimens: an immunohistochemical characterization of tumorsphere differentiation.Cancer cell international · 2016Article
- EGFR Amplification and Glioblastoma Stem-Like Cells.Stem cells international · 2015Review
- Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer stem cells (CSCs) have been reported to be critical in the initiation, maintenance, and progression of cancers. The expression of stem cell markers, such as podoplanin (PDPN), CD133, and nestin, may have been correlated with malignant progression. However, the effects of CSCs and stem cell markers on clinical outcomes in cancer patients remain unclear. In this study, we assessed the prognostic roles of glioma CSCs (gCSCs) isolation and stem cell markers in patients with primary glioblastoma (pGBM). A cohort of 39 patients with pGBM was separated into two groups, those positive or negative for gCSCs, and the correlation between gCSC and patient survival was evaluated. We observed significantly different cumulative survival (P = 0.045) when comparing patients positive for gCSCs patients and negative for gCSC. Among the patients positive for gCSCs, we observed no significant differences in survival between those whose gCSCs were each positive or negative for PDPN, CD133, or nestin. This study strongly supports the prognostic value of gCSCs isolation on the survival of patients with pGBM.
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Registered trials
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