Evidence map›Paper›PMID 25579968›Full record

ReviewMaterials science & engineering. C, Materials for biological applications2015

Current wound healing procedures and potential care.

Michael B Dreifke, Amil A Jayasuriya, Ambalangodage C Jayasuriya

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Materials science & engineering. C, Materials for biological applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03433820 (A Single-arm, Observational Study to Explore and Characterize Wound Healing After Skin Punch Biopsies in Healthy Volunteers), which is not on this map. Cited by 158 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 2 pooled it
23.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03433820 nacompletednot on this mapstarted 2017, after this paper: background citation

A Single-arm, Observational Study to Explore and Characterize Wound Healing After Skin Punch Biopsies in Healthy Volunteers

TypeinterventionalSponsorCentre for Human Drug Research, NetherlandsRan2017 to 2018Enrolled18ConditionsWound HealingArmsObservation of wound healing
3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 2 syntheses or guidelines pooled it, 523 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Pharmaceutical biology · 2026
    Article
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  6. Review
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  15. Exploring New Horizons in Wound Healing: A Comprehensive Analysis.Recent advances in inflammation & allergy drug discovery · 2026
    Review
  16. Article
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  18. Review
  19. Article
  20. Article

98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Michael B DreifkeDepartment of Orthopaedic Surgery, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH 43614-5807, USA.
Amil A JayasuriyaUndergraduate Program, Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Ambalangodage C JayasuriyaDepartment of Orthopaedic Surgery, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH 43614-5807, USA. Electronic address: a.jayasuriya@utoledo.edu.
University of Toledo · USHarvard University · US

Funding

Multifunctional bone putty for craniomaxillofacial bone repairR01DE023356 · NIDCR · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI JAYASURIYA, AMBALANGODAGE CHAMPA · 2013 to 2017
$2.0M
NIDCR NIH HHS R01 DE023356NIDCR NIH HHS R01DE023356
6 · The paper itself

Abstract

In this review, we describe current and future potential wound healing treatments for acute and chronic wounds. The current wound healing approaches are based on autografts, allografts, and cultured epithelial autografts, and wound dressings based on biocompatible and biodegradable polymers. The Food and Drug Administration approved wound healing dressings based on several polymers including collagen, silicon, chitosan, and hyaluronic acid. The new potential therapeutic intervention for wound healing includes sustained delivery of growth factors, and siRNA delivery, targeting microRNA, and stem cell therapy. In addition, environment sensors can also potentially utilize to monitor and manage microenvironment at wound site. Sensors use optical, odor, pH, and hydration sensors to detect such characteristics as uric acid level, pH, protease level, and infection - all in the hopes of early detection of complications.

Indexed as

Biological DressingsWound HealingAcute DiseaseCell- and Tissue-Based TherapyCellular MicroenvironmentChitosanChronic DiseaseCollagenHumansHyaluronic AcidIntercellular Signaling Peptides and ProteinsMicroRNAsRNA, Small InterferingSiliconWounds and InjuriesChitosanCollagenHyaluronic AcidIntercellular Signaling Peptides and ProteinsMicroRNAsRNA, Small InterferingSiliconChronic woundsGrowth factorsSensorssiRNAStem cellsWound dressingsWound healing

Identifiers

PMID25579968
PMCPMC4443476
OpenAlexW2047705770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.