ArticleDocumenta ophthalmologica. Advances in ophthalmology2015
Rod and cone contributions to the dark-adapted 15-Hz flicker electroretinogram.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The mesopic negative response (MeNR): a novel approach to assess retinal ganglion cell function within the rod pathway.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina.Frontiers in ophthalmology · 2023Article
- Elucidation of Cellular Mechanisms That Regulate the Sustained Contraction and Relaxation of the Mammalian Iris.Investigative ophthalmology & visual science · 2020Article
- Harmonization of Outcomes and Vision Endpoints in Vision Restoration Trials: Recommendations from the International HOVER Taskforce.Translational vision science & technology · 2020Article
- Rod and Cone Coupling Modulates Photopic ERG Responses in the Mouse Retina.Frontiers in cellular neuroscience · 2020Article
- AMPLITUDE LOSS OF THE HIGH-FREQUENCY FLICKER ELECTRORETINOGRAM IN EARLY DIABETIC RETINOPATHY.Retina (Philadelphia, Pa.) · 2019Article
- Nonlinearities in the flicker electroretinogram: A tool for studying retinal dysfunction applied to early-stage diabetic retinopathy.Vision research · 2019Article
- Cone Photoreceptor Dysfunction in Early-Stage Diabetic Retinopathy: Association Between the Activation Phase of Cone Phototransduction and the Flicker Electroretinogram.Investigative ophthalmology & visual science · 2019Article
- Temporal Frequency Abnormalities in Early-Stage Diabetic Retinopathy Assessed by Electroretinography.Investigative ophthalmology & visual science · 2018Article
- Rod Electroretinograms Elicited by Silent Substitution Stimuli from the Light-Adapted Human Eye.Translational vision science & technology · 2016Article
- Abnormal 8-Hz flicker electroretinograms in carriers of X-linked retinoschisis.Documenta ophthalmologica. Advances in ophthalmology · 2016Article
- A method for estimating intrinsic noise in electroretinographic (ERG) signals.Documenta ophthalmologica. Advances in ophthalmology · 2015Article
- Rod- and cone-isolated flicker electroretinograms and their response summation characteristics.Visual neuroscience · 2015Article
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5 authors.
Funding
Abstract
purposeTo evaluate rod and cone contributions to the dark-adapted 15-Hz flicker electroretinogram (ERG) across a broad range of stimulus luminances by comparing rod-isolating (ERGR), cone-isolating (ERGC), and non-receptor-specific (ERGR+C) responses.
methodsDark-adapted, full-field 15-Hz ERGs were obtained from four normally sighted subjects (ages 29-36 years) using a four-primary LED-based stimulating system. The primaries were either modulated sinusoidally in phase (ERGR+C) or were modulated in counter-phase to achieve rod isolation (ERGR) or cone isolation (ERGC) by means of triple silent substitution. Measurements were made for a broad range of luminances (-2.5 to 1.8 log scot. cd/m(2) in 0.2 log unit steps). Fourier analysis was used to obtain the amplitude and phase of the fundamental response component at each stimulus luminance.
resultsStimulus luminance had different effects on response amplitudes and phases under the three paradigms. Specifically, ERGC amplitude and phase increased monotonically as luminance increased. The effects on ERGR+C and ERGR were complex: ERGR+C and ERGR amplitude was small and the phase decreased for low luminances, whereas amplitude and phase increased sharply at moderate luminances. For high luminances, ERGR+C amplitude and phase increased, whereas ERGR amplitude decreased and phase was approximately constant.
conclusionsAt low luminances, the ERGR+C and ERGR functions can be attributed to interactions between two rod pathways. At high luminances, the functions can be accounted for by interactions between rod and cone pathways (ERGR+C) or rod insensitivity (ERGR). The ERGR paradigm minimizes cone intrusion, permitting assessment of rod function over a large range of luminance levels.
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