ReviewCurrent opinion in chemical biology2015
Artificial metalloenzymes derived from three-helix bundles.
Review in Current opinion in chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Probing anion recognition in a cobalt(II) de novo designed metalloprotein.Journal of inorganic biochemistry · 2026Article
- Breaking symmetry: Metal-guided assembly of heterotrimeric coiled coils.Methods in enzymology · 2025Article
- De novo design of four-helix bundle proteins to bind metalloporphyrin cofactors.Methods in enzymology · 2025Article
- Review
- Biocatalysts Based on Peptide and Peptide Conjugate Nanostructures.Biomacromolecules · 2021Review
- Tools and Methods for Investigating Synthetic Metal-Catalyzed Reactions in Living Cells.ACS catalysis · 2021Article
- Stepwise nitrosylation of the nonheme iron site in an engineered azurin and a molecular basis for nitric oxide signaling mediated by nonheme iron proteins.Chemical science · 2021Article
- Metal-Templated Design of Chemically Switchable Protein Assemblies with High-Affinity Coordination Sites.Angewandte Chemie (International ed. in English) · 2020Article
- Review
- Rational Design of Artificial Metalloproteins and Metalloenzymes with Metal Clusters.Molecules (Basel, Switzerland) · 2019Review
- Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster.Biopolymers · 2018Article
- Development of a Rubredoxin-Type Center Embedded in a de Dovo-Designed Three-Helix Bundle.Biochemistry · 2018Article
- Design of artificial metalloproteins/metalloenzymes by tuning noncovalent interactions.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018Review
- Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme.Nature communications · 2017Article
- Computational approaches forBioscience reports · 2017Review
- Design and engineering of artificial oxygen-activating metalloenzymes.Chemical Society reviews · 2016Review
- Rational Design of Dual Active Sites in a Single Protein Scaffold: A Case Study of Heme Protein in Myoglobin.ChemistryOpen · 2016Article
- Minimal Functional Sites in Metalloproteins and Their Usage in Structural Bioinformatics.International journal of molecular sciences · 2016Review
- Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation.Nature chemistry · 2015Article
- De novo protein design as a methodology for synthetic bioinorganic chemistry.Accounts of chemical research · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Three-helix bundles and coiled-coil motifs are well-established de novo designed scaffolds that have been investigated for their metal-binding and catalytic properties. Satisfaction of the primary coordination sphere for a given metal is sufficient to introduce catalytic activity and a given structure may catalyze different reactions dependent on the identity of the incorporated metal. Here we describe recent contributions in the de novo design of metalloenzymes based on three-helix bundles and coiled-coil motifs, focusing on non-heme systems for hydrolytic and redox chemistry.
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Registered trials
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