ReviewMetallomics : integrated biometal science2015
Overcoming the concentration-dependence of responsive probes for magnetic resonance imaging.
Review in Metallomics : integrated biometal science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Polymer Network-Based Nanogels and Microgels: Design, Classification, Synthesis, and Applications in Drug Delivery.Gels (Basel, Switzerland) · 2025Review
- Magnetic-susceptibility-dependent ratiometric probes for enhancing quantitative MRI.Nature biomedical engineering · 2025Article
- A swelling probe for nitric oxide.Nature materials · 2025Article
- The role of responsive MRI probes in the past and the future of molecular imaging.Chemical science · 2024Review
- The Development of a Smart Magnetic Resonance Imaging and Chemical Exchange Saturation Transfer Contrast Agent for the Imaging of Sulfatase Activity.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Outersphere Approach to Increasing the Persistance of Oxygen-Sensitive Europium(II)-Containing Contrast Agents for Magnetic Resonance Imaging with Perfluorocarbon Nanoemulsions toward Imaging of Hypoxia.Advanced healthcare materials · 2023Article
- Toward quantification of hypoxia using fluorinated EuProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dual-Mode Tumor Imaging Using Probes That Are Responsive to Hypoxia-Induced Pathological Conditions.Biosensors · 2022Review
- Article
- RGD-Peptide Functionalization Affects theJournal of medicinal chemistry · 2021Article
- Magnetic resonance thermometry using a GdChemical communications (Cambridge, England) · 2021Article
- Measurement of the Dissociation of EuInorganic chemistry · 2020Article
- Oxidative stress measured in vivo without an exogenous contrast agent using QUEST MRI.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Review
- Article
- Synthesis, Characterization, and Handling of EuFrontiers in chemistry · 2018Review
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- A new paramagnetically shifted imaging probe for MRI.Magnetic resonance in medicine · 2017Article
- The Role of Coordination Environment and pH in Tuning the Oxidation Rate of Europium(II).Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Myelin-targeted, texaphyrin-based multimodal imaging agent for magnetic resonance and optical imaging.Contrast media & molecular imaging · 2016Article
- Spectroscopic Characterization of the 3+ and 2+ Oxidation States of Europium in a Macrocyclic Tetraglycinate Complex.Inorganic chemistry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In magnetic resonance imaging, contrast agents are molecules that increase the contrast-to-noise ratio of non-invasively acquired images. The information gained from magnetic resonance imaging can be increased using responsive contrast agents that undergo chemical changes, and consequently changes to contrast enhancement, for example in response to specific biomarkers that are indicative of diseases. A major limitation with modern responsive contrast agents is concentration-dependence that requires the concentration of contrast agent to be known: an extremely challenging task in vivo. Here, we review advances in several strategies aimed at overcoming the concentration-dependent nature of responsive contrast agents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.