Trial reportInternational journal of colorectal disease2015
General anesthesia combined with epidural anesthesia ameliorates the effect of fast-track surgery by mitigating immunosuppression and facilitating intestinal functional recovery in colon cancer patients.
Trial report in International journal of colorectal disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Interventional factors influencing natural killer cell immunity in colorectal cancer: a systematic review.Cancer immunology, immunotherapy : CII · 2025Pooled it
- Effect of combined epidural-general anesthesia on long-term survival of patients with colorectal cancer: a meta-analysis of cohort studies.International journal of colorectal disease · 2022Pooled it
- Epidural analgesia versus patient-controlled intravenous analgesia for pain following intra-abdominal surgery in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, vomiting and pain after abdominal surgery.The Cochrane database of systematic reviews · 2016Pooled it
- Pooled it
- Efficacy of quadratus lumborum block type 3 on postoperative cell-mediated immunity and analgesia for laparoscopic radical gastrectomy: a prospective randomized controlled trial.Surgical endoscopy · 2025Trial
- Combined anesthesia shows better curative effect and less perioperative neuroendocrine disorder than general anesthesia in early stage NSCLC patients.The Journal of international medical research · 2019Trial
- Anesthesia, analgesia, and immunonutrition in perioperative immune homeostasis: a focused mini review.Frontiers in nutrition · 2026Review
- Artificial intelligence algorithms for predicting post-operative ileus after laparoscopic surgery.Heliyon · 2024Article
- Effect of different anesthetic modalities with multimodal analgesia on postoperative pain level in colorectal tumor patients.World journal of gastrointestinal oncology · 2024Article
- Propofol ECFrontiers in medicine · 2023Article
- Monocyte programming by cancer therapy.Frontiers in immunology · 2022Review
- Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer.Open medicine (Warsaw, Poland) · 2022Article
- [Epidural block associated with improved long-term survival after surgery for colorectal cancer: A retrospective cohort study with propensity score matching].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
- Epidural analgesia and mortality after colorectal cancer surgery: A retrospective cohort study.Annals of medicine and surgery (2012) · 2021Article
- Impact of anesthesia methods on perioperative systemic inflammation and long-term outcomes in patients undergoing surgery for hepatocellular carcinoma: a propensity score-matched analysis.Annals of translational medicine · 2021Article
- Dezocine promotes T lymphocyte activation and inhibits tumor metastasis after surgery in a mouse model.Investigational new drugs · 2020Article
- Influence of the Enhanced Recovery After Surgery Protocol on Postoperative Inflammation and Short-term Postoperative Surgical Outcomes After Colorectal Cancer Surgery.Annals of coloproctology · 2020Article
- Effects of epidural combined with general anesthesia versus general anesthesia alone in gastric cancer surgery: a propensity score matching analysis.Annals of translational medicine · 2020Article
- Effect of Preoperative Opioid Use on Adverse Outcomes, Medical Spending, and Persistent Opioid Use Following Elective Total Joint Arthroplasty in the United States: A Large Retrospective Cohort Study of Administrative Claims Data.Pain medicine (Malden, Mass.) · 2020Observational
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to investigate the influence of anesthetic methods on markers of anti-tumor immunity and intestinal functions in fast-track surgery in colon cancer (CC) patients during the perioperative period. PATIENTS AND
methodsA total of 53 patients with American Society of Anesthesiologists (ASA) I-II status randomly received general anesthesia (G group, n = 27) or general anesthesia combined with epidural anesthesia (E group, n = 26) for surgical tumor resection. The recovery times of intestinal function were evaluated in both groups postoperatively. The frequencies of different subsets of CD4+ T cells and myeloid-derived suppressor cells and C-reactive protein (CRP) were measured by flow cytometry and enzyme-linked immunosorbent assay, respectively, before anesthesia (t0), 1 h after the beginning of surgery (t1), 1 h after the end of surgery (t2), and on day 2 (t3) and day 5 (t4) post-surgery.
resultsThere was no significant difference in demographic characteristics between the two groups, but the E group of patients received significantly lower amounts of morphine and sevoflurane. In comparison with those in the G group, significantly greater numbers of lymphocytes and elevated frequencies of Th1 cells were detected at t3 and t4 post-surgery in the E group (p < 0.01). Significantly lower percentages of Th2 cells and regulatory T cells were detected in the E group at t2-4 post-surgery. Whereas the levels of plasma CRP increased post-surgery in both groups, the levels of CRP were significantly lower in the E group than those in the G group at t3-4 post-surgery (p < 0.05). The times to the first flatus and to tolerate a full diet were significantly shorter in the E group than those in the G group (p < 0.01).
conclusionGeneral anesthesia combined with epidural anesthesia plays an important role in fast-track surgery, mitigating the surgical stress-related impairment of anti-tumor immune responses and hastening the recovery of intestinal function. This combination might also help to improve long-term outcomes for CC patients.
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