ArticleNucleic acids research2015
DICER-dependent biogenesis of let-7 miRNAs affects human cell response to DNA damage via targeting p21/p27.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Pressure Loading Induces DNA Damage in Human Hepatocyte Line L02 Cells via the ERK1/2-Dicer Signaling Pathway.International journal of molecular sciences · 2022Article
- Deficiency of DICER reduces the invasion ability of trophoblasts and impairs the pro-angiogenic effect of trophoblast-derived microvesicles.Journal of cellular and molecular medicine · 2020Article
- A Regulator of Metabolic Reprogramming: MicroRNA Let-7.Translational oncology · 2019Article
- Ionizing radiation-induced growth in soft agar is associated with miR-21 upregulation in wild-type and DNA double strand break repair deficient cells.DNA repair · 2019Article
- Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability.Cell death & disease · 2019Article
- Next-generation sequencing reveals two populations of damage-induced small RNAs at endogenous DNA double-strand breaks.Nucleic acids research · 2018Article
- Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.Nucleic acids research · 2017Article
- Global mapping of miRNA-target interactions in cattle (Bos taurus).Scientific reports · 2017Article
- miR-21-mediated Radioresistance Occurs via Promoting Repair of DNA Double Strand Breaks.The Journal of biological chemistry · 2017Article
- Targeting MicroRNAs in Prostate Cancer Radiotherapy.Theranostics · 2017Review
- Homology directed repair is unaffected by the absence of siRNAs in Drosophila melanogaster.Nucleic acids research · 2016Article
- ΔNp63/DGCR8-Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer.Cancer cell · 2016Article
- Low miR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma.Molecular medicine (Cambridge, Mass.) · 2016Article
- Systematic study of cis-antisense miRNAs in animal species reveals miR-3661 to target PPP2CA in human cells.RNA (New York, N.Y.) · 2016Article
Corrections and comments
- Retraction · 2022-11-30Concerns/Issues about Image · Investigation by Company/Institution · Investigation by Journal/Publisher · Manipulation of Images · Original Data and/or Images not Provided and/or not Available · Unreliable Results and/or Conclusions · Upgrade/Update of Prior Notice(s) · · see also: https://pubpeer.com/publications/D3BAD4F56E914C444ED0287839AF92
- Expression of concern · 2022-06-18Concerns/Issues about Image · Investigation by Journal/Publisher · Updated to Retraction · · see also: https://pubpeer.com/publications/D3BAD4F56E914C444ED0287839AF92
- Expression of concern
- Retracted
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Recently, it was reported that knockdown of DICER reduced the ATM-dependent DNA damage response and homologous recombination repair (HRR) via decreasing DICER-generated small RNAs at the damage sites. However, we found that knockdown of DICER dramatically increased cell resistance to camptothecin that induced damage required ATM to facilitate HRR. This phenotype is due to a prolonged G1/S transition via decreasing DICER-dependent biogenesis of miRNA let-7, which increased the p21(Waf1/Cip1)/p27(Kip1) levels and resulted in decreasing the HRR efficiency. These results uncover a novel function of DICER in regulating the cell cycle through miRNA biogenesis, thus affecting cell response to DNA damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.