Evidence map›Paper›PMID 25578933›Full record

ReviewAsian journal of andrology

Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network.

George Kulik

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Androgens modulate endometrial function.Medical molecular morphology · 2025
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

George KulikLife Sciences Program, College of Science, Alfaisal University, Riyadh 11533, Saudi Arabia; Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA, .
Alfaisal University · SA

Funding

A novel mechanism of AKT activation regulated by YY1 bindingR21CA182248 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KULIK, GEORGE A · 2015 to 2016
$371k
6 · The paper itself

Abstract

Targeting the androgen receptor axis provides only temporary relief for advanced prostate cancer, which often evolves into androgen-independent disease. The wide variety of signaling mechanisms connected with the pathophysiology of androgen-independent prostate cancer poses both conceptual and practical challenges for the design of efficient therapies. Analysis of apoptosis regulation in prostate cancer suggests the potential value of a systems approach that integrates information on the topology of the antiapoptotic signaling network, the signal transduction pathways that inhibit apoptosis, and the expression of proteins of the Bcl2 family. This approach could be used to identify patients most likely to respond to treatments with drugs that inhibit the signaling pathways controlling apoptosis.

Indexed as

Systems AnalysisAntineoplastic AgentsApoptosisbcl-Associated Death ProteinHumansMaleMyeloid Cell Leukemia Sequence 1 ProteinPrecision MedicineProstatic NeoplasmsReceptors, AndrogenSignal TransductionAntineoplastic AgentsAR protein, humanBAD protein, humanbcl-Associated Death ProteinMCL1 protein, humanMyeloid Cell Leukemia Sequence 1 ProteinReceptors, Androgen

Identifiers

PMID25578933
PMCPMC4430953
OpenAlexW2043883305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.