Evidence map›Paper›PMID 25578822›Full record

ArticleDer Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft2015

[Immunological graft rejection with Khodadoust line after "Descemet stripping automated endothelial keratoplasty" (DSAEK)].

M Fiorentzis, A Viestenz, B Seitz

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

M FiorentzisKlinik für Augenheilkunde, Universitätsklinikum des Saarlandes UKS, Kirrberger Str. 100, Gebäude 22, 66424, Homburg/Saar, Deutschland. miltiadis.fiorentzis@uks.eu.
A ViestenzKlinik für Augenheilkunde, Universitätsklinikum des Saarlandes UKS, Kirrberger Str. 100, Gebäude 22, 66424, Homburg/Saar, Deutschland.
B SeitzKlinik für Augenheilkunde, Universitätsklinikum des Saarlandes UKS, Kirrberger Str. 100, Gebäude 22, 66424, Homburg/Saar, Deutschland.
Ophthalmology Clinic · DEUniversitätsklinikum des Saarlandes · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver the past decade endothelial keratoplasty has become the treatment of choice for patients with corneal endothelial dysfunction.

methods"Descemet stripping automated endothelial keratoplasty" (DSAEK) is one of the most widespread forms of posterior endothelial keratoplasty. An improvement of visual acuity is achieved more quickly after DSAEK and the reduced amount of transplanted tissue in DSAEK seems to result in fewer instances of immunological graft rejection. PROBLEMS: The clinical signs of immunological graft rejection after DSAEK are not yet well known. Typically, an immunological rejection episode is combined with the presence of corneal edema, Descemet folds and retrocorneal precipitates restricted to the graft but a classical Khodadoust line seems to be rare.

resultsThe quick response after the combination of high-dose topical and systemic steroid therapy with steroid injection (80 μg fortecortin) in the anterior chamber in our patient confirms the necessity of a prompt and rapid immunosuppression.

conclusionsAlthough the risk of graft rejection after DSAEK is rare, the use of immunosuppressants is important in both acute and long-term postoperative care of endothelial corneal transplantation.

Indexed as

AgedDescemet Stripping Endothelial KeratoplastyDiagnosis, DifferentialGraft RejectionHumansImmunosuppressive AgentsKeratitisMaleSteroidsTreatment OutcomeImmunosuppressive AgentsSteroidsCorneal transplantationImmune reactionKeratoplastySteroid therapyVisual acuity

Identifiers

PMID25578822
OpenAlexW2129641761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.