ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- The sodium leak channel NALCN in Drd2Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Dopamine D2S/D2L Receptor Regulation of Alcohol-Induced Reward and Signalling.Addiction biology · 2025Article
- Pre and postnatal exposure to glyphosate-based herbicides and potential neurodevelopmental outcomes: a systematic review of animal and epidemiological studies.Toxicological research · 2025Review
- Levo-Stepholidine as a Potential Cognitive Enhancer: Insights into Executive Function and Memory Improvements.Biomedicines · 2024Article
- Updating the striatal-pallidal wiring diagram.Nature neuroscience · 2024Review
- Low Dopamine D2 Receptor Expression Drives Gene Networks Related to GABA, cAMP, Growth and Neuroinflammation in Striatal Indirect Pathway Neurons.Biological psychiatry global open science · 2023Article
- Overexpression of wild type glycine alpha 1 subunit rescues ethanol sensitivity in accumbal receptors and reduces binge drinking in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- How changes in dopamine D2 receptor levels alter striatal circuit function and motivation.Molecular psychiatry · 2022Review
- Rethinking the Approach to Preclinical Models of Anorexia Nervosa.Current psychiatry reports · 2022Review
- Article
- A versatile GPCR toolkit to track in vivo neuromodulation: not a one-size-fits-all sensor.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Dopamine D2 receptor overexpression in the nucleus accumbens core induces robust weight loss during scheduled fasting selectively in female mice.Molecular psychiatry · 2021Article
- Dopamine D2R upregulation in ventral striatopallidal neurons does not affect Pavlovian or go/no-go learning.Behavioral neuroscience · 2021Article
- A Gain-of-Function Variant in Dopamine D2 Receptor and Progressive Chorea and Dystonia Phenotype.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Orexin-A up-regulates dopamine D2 receptor and mRNA in the nucleus accumbens Shell.Molecular biology reports · 2020Article
- Chemogenetic selective manipulation of nucleus accumbens medium spiny neurons bidirectionally controls alcohol intake in male and female rats.Scientific reports · 2020Article
- Emerging roles of striatal dopamine D2 receptors in motivated behaviour: Implications for psychiatric disorders.Basic & clinical pharmacology & toxicology · 2020Review
- Pre- and postnatal exposure to glyphosate-based herbicide causes behavioral and cognitive impairments in adult mice: evidence of cortical ad hippocampal dysfunction.Archives of toxicology · 2020Article
- Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum.Nature communications · 2020Article
- A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors.Cell reports · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Brain imaging studies performed in humans have associated low striatal dopamine release and D2R binding with alcohol dependence. Conversely, high striatal D2R binding has been observed in unaffected members of alcoholic families suggesting that high D2R function may protect against alcohol dependence. A possible protective role of increased D2R levels in the striatum is further supported by preclinical studies in non-human primates and rodents. Here, we determined whether there is a causal relationship between D2R levels and alcohol intake. To this end, we upregulated D2R expression levels in the nucleus accumbens of the adult mouse, but selectively restricted the upregulation to the indirect striatal output pathway, which endogenously expresses D2Rs. After overexpression was established, mice were tested in two models of free-choice alcohol drinking: the continuous and intermittent access two-bottle choice models. As anticipated, we found that D2R upregulation leads to hyperactivity in the open field. Contrary to our expectation, D2R upregulation did not reduce alcohol intake during continuous or intermittent access or when alcohol drinking was tested in the context of aversive outcomes. These data argue against a protective role of accumbal indirect pathway D2Rs in alcohol consumption but emphasize their importance in promoting locomotor activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.