ArticleCell reports2015
Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress-induced inflammation.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 2 of them syntheses that pooled it.
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Who cites it
144 citing papers in PubMed, 2 syntheses or guidelines pooled it, 229 citations in OpenAlex.
- Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review.Cells · 2025Pooled it
- A systematic review of metabolomic profiling of gastric cancer and esophageal cancer.Cancer biology & medicine · 2020Pooled it
- Chronic viral infection aggravates white adipose tissue dysfunction and liver pathology in obesity.Molecular metabolism · 2026Article
- Spatial transcriptomics supports a role for SOX4-driven signaling throughout the disease course of biliary atresia.Hepatology communications · 2026Article
- Alginate oligosaccharides prevent and treat obesity by promoting brown fat thermogenesis rather than regulating gut microbiota.Journal of advanced research · 2026Article
- Multi-omics dissection of heat stress reveals CIITA as a central regulator of metabolic thermotolerance in cattle (Bos taurus).Communications biology · 2026Article
- Effect of dietary Bacillus subtilis on basic chemical composition, free amino acids, fatty acids and volatile organic compounds in broiler meat.Poultry science · 2026Article
- Associations between Metabolic Syndrome Indicators and Colon Polyps: A Mendelian Randomization Study.Endocrinology and metabolism (Seoul, Korea) · 2026Article
- Palmitic acid induces UCP1-independent mitochondrial depolarization specifically in brown adipose tissue.The Journal of biological chemistry · 2026Article
- Transplantation of Soluble Epoxide Hydrolase Inhibitor-Treated Human Brown Adipocytes Promotes Adipose Tissue Activation in High-Fat-Diet-Fed Nude Mice.International journal of molecular sciences · 2026Article
- Oleic acid improves pathological changes in Aβ1-42-induced astrocytes and Alzheimer's disease mouse models through PKA/ACACB/CPT1A.Frontiers in neuroscience · 2026Article
- β3-adrenergic receptor agonist causes acute thermogenic metabolic crisis in ACSS1-K635Q knock-in mice.International journal of biological sciences · 2026Article
- Molecular signatures and machine learning driven stress biomarkers for rainbow trout aquaculture and climate adaptation.Scientific reports · 2025Article
- Dysregulated hippocampal fatty acid metabolism following intermittent hypoxemia-induced neonatal brain injury is rescued by treatment with acetate.Nature communications · 2025Article
- Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice.Science advances · 2025Article
- 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction.Nature metabolism · 2025Article
- Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy.Nature communications · 2025Article
- Brown and beige adipose tissue-derived metabokine and lipokine inter-organ signalling in health and disease.Experimental physiology · 2025Review
- Irisin reverses high-fat diet-induced metabolic dysfunction via activation of brown adipose tissue in mice.International journal of obesity (2005) · 2025Article
- Therapeutic Potential of Santa Herba Extract in Obesity: Impact on Lipid Metabolism and Hormonal Balance.Food science & nutrition · 2025Article
84 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To understand the contribution of adipose tissue fatty acid oxidation to whole-body metabolism, we generated mice with an adipose-specific knockout of carnitine palmitoyltransferase 2 (CPT2(A-/-)), an obligate step in mitochondrial long-chain fatty acid oxidation. CPT2(A-/-) mice became hypothermic after an acute cold challenge, and CPT2(A-/-) brown adipose tissue (BAT) failed to upregulate thermogenic genes in response to agonist-induced stimulation. The adipose-specific loss of CPT2 resulted in diet-dependent changes in adiposity but did not result in changes in body weight on low- or high-fat diets. Additionally, CPT2(A-/-) mice had suppressed high-fat diet-induced oxidative stress and inflammation in visceral white adipose tissue (WAT); however, high-fat diet-induced glucose intolerance was not improved. These data show that fatty acid oxidation is required for cold-induced thermogenesis in BAT and high-fat diet-induced oxidative stress and inflammation in WAT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.