ArticleJournal of materials science. Materials in medicine2015
Characterization and in vitro evaluation of electrospun chitosan/polycaprolactone blend fibrous mat for skin tissue engineering.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 98 citations in OpenAlex.
- Improving Stability and Mechanical Strength of Electrospun Chitosan-Polycaprolactone Scaffolds Using Genipin Cross-linking for Biomedical Applications.Macromolecular rapid communications · 2025Article
- Manufacturing Radially Aligned PCL Nanofibers Reinforced With Sulfated Levan and Evaluation of its Biological Activity for Healing Tympanic Membrane Perforations.Macromolecular bioscience · 2025Article
- Managing Oxidative Stress Using Vitamin C to Improve Biocompatibility of Polycaprolactone for Bone RegenerationACS omega · 2024Article
- Unidirectional gene delivery electrospun fibrous membrane via charge repulsion for tendon repair.Bioactive materials · 2024Article
- An Innovative Approach for Elemental Mercury Adsorption Using X-ray Irradiation and Electrospun Nylon/Chitosan Nanofibers.Polymers · 2024Article
- Article
- Optimization of Electrospun TORLONPolymers · 2024Article
- Alternating Current Electrospinning of Polycaprolactone/Chitosan Nanofibers for Wound Healing Applications.Polymers · 2024Article
- The wound healing effect of polycaprolactone-chitosan scaffold coated with a gel containing Zataria multiflora Boiss. volatile oil nanoemulsions.BMC complementary medicine and therapies · 2024Article
- Nanomaterials-incorporated hydrogels for 3D bioprinting technology.Nano convergence · 2023Review
- Monitoring Cell Adhesion on Polycaprolactone-Chitosan Films with Varying Blend Ratios by Quartz Crystal Microbalance with Dissipation.ACS omega · 2023Article
- Review
- Review
- Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffolds.Polymers · 2022Article
- Three-Dimensional Culture ofInsects · 2021Article
- Tailored PCL Scaffolds as Skin Substitutes Using Sacrificial PVP Fibers and Collagen/Chitosan Blends.International journal of molecular sciences · 2020Article
- Chitosan based bioactive materials in tissue engineering applications-A review.Bioactive materials · 2020Review
- Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids.Frontiers in bioengineering and biotechnology · 2019Article
- Osteogenic Potential of Pre-Osteoblastic Cells on a Chitosan-graft-Polycaprolactone Copolymer.Materials (Basel, Switzerland) · 2018Article
- Biomaterials for Skin Substitutes.Advanced healthcare materials · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The electrospinning technique allows engineering biomimetic scaffolds within micro to nanoscale range mimicking natural extracellular matrix (ECM). Chitosan (CS) and polycaprolactone (PCL) were dissolved in a modified solvent mixture consisting of formic acid and acetone (3:7) and mixed in different weight ratios to get chitosan-polycaprolactone [CS-PCL] blend solutions. The CS-PCL blend polymer was electrospun in the same solvent system and compared with PCL. The physicochemical characterization of the electrospun fibrous mats was done using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), tensile test, swelling properties, water contact angle (WCA) analysis, surface profilometry and thermo gravimetric analysis (TGA). The CS-PCL fibrous mat showed decreased hydrophobicity. The CS-PCL mats also showed improved swelling property, tensile strength, thermal stability and surface roughness. The cytocompatibility of the CS-PCL and PCL fibrous mats were examined using mouse fibroblast (L-929) cell line by direct contact and cellular activity with extract of materials confirmed non-cytotoxic nature. The potential of CS-PCL and PCL fibrous mats as skin tissue engineering scaffolds were assessed by cell adhesion, viability, proliferation and actin distribution using human keratinocytes (HaCaT) and L-929 cell lines. Results indicate that CS-PCL is a better scaffold for attachment and proliferation of keratinocytes and is a potential material for skin tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.