ArticleJournal of materials science. Materials in medicine2015
Microstructured zirconia surfaces modulate osteogenic marker genes in human primary osteoblasts.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Cellular Responses at the Zirconia Dental Implant Interface: A Comprehensive Review.Journal of functional biomaterials · 2026Review
- Osseointegration properties of niobia-modified yttria-stabilized zirconia implant surface: anThe journal of advanced prosthodontics · 2025Article
- Bonding Strategies for Zirconia Fixed Restorations: A Scoping Review of Surface Treatments, Cementation Protocols, and Long-Term Durability.Biomimetics (Basel, Switzerland) · 2025Review
- Zirconia in Dental Implantology: A Review of the Literature with Recent Updates.Bioengineering (Basel, Switzerland) · 2025Review
- Comparison of Zirconia Implant Surface Modifications for Optimal Osseointegration.Journal of functional biomaterials · 2024Review
- [Effects of surface treatment on the phase and fracture strength of yttria- and magnesia-stabilized zirconia implants].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Surface Structure of Zirconia Implants: An Integrative Review Comparing Clinical Results with Preclinical and In Vitro Data.Materials (Basel, Switzerland) · 2022Review
- Surface modification of zirconia dental implants by laser texturing.Lasers in medical science · 2022Review
- Laser Structured Dental Zirconium for Soft Tissue Cell Occupation-Importance of Wettability Modulation.Materials (Basel, Switzerland) · 2022Article
- Improving the Intercellular Uptake and Osteogenic Potency of Calcium Phosphate via Nanocomplexation with the RALA Peptide.Nanomaterials (Basel, Switzerland) · 2020Article
- The Anchorage of Bone Cells onto an Yttria-Stabilized Zirconia Surface with Mild Nano-Micro Curved Profiles.Dentistry journal · 2020Article
- Efficacy of Plasma-Polymerized Allylamine Coating of Zirconia after Five Years.Journal of clinical medicine · 2020Article
- Interactions of Osteoprogenitor Cells with a Novel Zirconia Implant Surface.Journal of functional biomaterials · 2020Article
- Zirconia surface modifications for implant dentistry.Materials science & engineering. C, Materials for biological applications · 2019Review
- Initial osteoblast adhesion and subsequent differentiation on zirconia surfaces are regulated by integrins and heparin-sensitive molecule.International journal of nanomedicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In dentistry, zirconia has been used since the early 1990s for endodontic posts, more recently for implant abutments and frameworks for fixed dental prostheses. Zirconia is biocompatible and mechanically strong enough to serve as implant material for oral implants. Although several zirconia implant systems are available, currently the scientific and clinical data for zirconia implants are not sufficient to recommend them for routine clinical use. Here the influence of microstructured yttria-stabilized zirconia (YZ) on human primary osteoblast (HOB) behavior was determined. YZ surfaces were treated by sandblasting (YZ-S), acid etching (YZ-SE) and additionally heat treatment (YZ-SEH). Morphological changes of HOB were determined by scanning electron microscopy. Actin cytoskeleton was investigated by laser scanning microscopy and analyzed by novel actin quantification software. Differentiation of HOB was determined by real time RT-PCR. Improved mechanical interlocking of primary HOB into the porous microstructure of the acid etched and additionally heat treated YZ-surfaces correlates with drastically increased osteocalcin (OCN) gene expression. In particular, OCN was considerably elevated in primary HOB after 3 days on YZ-SE (13-fold) as well as YZ-SEH (12-fold) surfaces. Shorter actin filaments without any favored orientation on YZ-SE and YZ-SEH surfaces are associated with higher roughness (Ra) values. Topographically modified yttria-stabilized zirconia is a likely material for dental implants with cell stimulating properties achieving or actually exceeding those of titanium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.